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(Luận văn thạc sĩ) investigate of albumin porous holow fe3o4 nanoparticles for dual drug delivery
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Mô tả chi tiết
THAI NGUYEN UNIVERSITY
UNIVERSITY OF AGRICULTURE AND FORESTRY
TRAN THI THUY HA
TOPIC TITTLE: INVESTIGATE OF ALBUMIN COATED POROUS
HOLLOW Fe3O4 NANOPARTICLES FOR DUAL DRUGS DELIVERY
BACHELOR THESIS
Study Mode: Full-time
Major: Environmental Science and Management
Faculty: International Training and Development Center
Batch: 2010-2015
Thai Nguyen, 15/01/2015
n
THAI NGUYEN UNIVERSITY
UNIVERSITY OF AGRICULTURE AND FORESTRY
TRAN THI THUY HA
TOPIC TITTLE: INVESTIGATE OF ALBUMIN COATED POROUS
HOLLOW Fe3O4 NANOPARTICLES FOR DUAL DRUGS DELIVERY
BACHELOR THESIS
Study Mode: Full-time
Major: Environmental Science and Management
Faculty: International Training and Development Center
Batch: 2010-2015
Thai Nguyen, 15/01/2015
n
ii
Thai Nguyen University of Agriculture and Forestry
Degree Program Bachelor of Environmental Science and Management
Student name Tran Thi Thuy Ha
Student ID DTN1053110065
Thesis Title Investigate of Albumin-Porous Holow Fe3O4 Nanoparticles for
Dual Drug Delivery
Supervisor(s) Prof. Huang Yu-Fen & Dr. Do Thi Ngoc Oanh
Abstract:
Dual-functional drug carrier has been a modern strategy in cancer treatment.
Photodynamic therapy (PDT) is a non-invasive treatment modality for selective
destruction of cancer malignant cells, which involves light irradiation, and a
photosensitizer for free radicals generation; hence archiving photocytotoxicity. On
the other hand, the use of a chemotherapeutic agent is most effective at killing cells
that are rapidly dividing. However, most of the photosensitizers and
chemotherapeutical agents lack of efficient bio-distribution and cellular uptake; for
instance the use of nanoparticles provides an ideal carrier of a photodynamic drug.
In the present work, a photosensitizer drug protoporphyrin IX (PpIX), and a
chemotherapeutic drug Doxorubicin (DOX), are encapsulated onto porous hollow
iron nanoparticles (PHNPs) via oil in water emulsion procedure using BSA as a
stabilizer, with the aim of a synergistic effect through a combination therapy.
Carriers were successfully characterized; sizes and charges were monitored via DLS
and Zeta Potential respectively. The intracellular uptake and localization of
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