Đánh giá hiệu quả phác đồ paclitaxel - carboptalin trong điều trị utpkptbn giai đoạn IIIB - IV tại bệnh viện ung bướu Hà Nội

DANH GIA HIEU QUA PHAC 0 0 PACLITAXEL - CARBOPLATIN TRONG DIEU TRj UTPKPTBN

GIAI DOAN IIIB-IV TAI BENH VIEN UNG BO ^ HA NOI

TOM TA T :

Myc tieu: Dinh gii hipu qui phac dd Paditaxel -

carboplatin tmng diiu tri UTPKPTBN giai dopn IIIB-IV tpi

bpnh vipn Ung Bir&u Ha Ngi

Phwong phap nghien ciru : Md ta tiin cim

Nghien ciru tre n 45 bpnh nhin ehin doan la

UTPKPTBN giai doan IIIB-IV duoc diiu tri phic do

Paditaxel -carboplatin. Danh gia dip img, th&i gian

song them vi cic tic dyng phy eua phic dd .

Ket qua: Tuoi tmng binh (58,4). Cac trieu chimg va

chat lirgng song dirge cai thipn. Dip img toan bg la

31,1% (khdng cd dap img hoan toan). Th&i gian song

them tmng binh la 10,4 thing. Ty lp song them 1nam la

34,7 %, th&i gian song them 2 nam la 6,7%. Tie dyng

phu khdng dang ke va nhanh hdi phyc. Khdng cd bpnh

nhan nao phai dimg diiu tri vl tie dung phy.

Tir khda: phac do Paditaxel -carboplatin, Ung Buou

Hi Ngi

SUMMARY

Evaluate the efficacy of Paelitaxel-earboplatin

regiment in treatment the stage IIIB-IV, non small cell

lung cancer at Hanoi Oncology hospital, from 2006

to 2009

Aim: To evaluate the efficacy of Paelitaxel￾earboplatin regiment in tmatment the stage IIIB-IV, non

small cell lung cancer at Hanoi Oncology hospital, from

2006 to 2009

Methods: Cohort study, a totall of fourty- five

patients (36 male, 9 female) diagnosed stage IIIB-IV,

non small cell lung cancer, treated with Paelitaxel￾earboplatin combination (Paditaxel 175mg/m2/ngay

tmyen tmh mpch ngay1; Carboplatin 300mg/ m2/ngay

tmyen tmh mpch ngay 1- Chu ky 21 ngay)

Respone evaluate after fishing treatment.

Results: The median age Is 58,4. The symtoms

decreased after treatment, there by showing that

Paditaxel- carboplatin regimen enhanced the quality of

life.

- Overall respone rate (Partial respone) was 31,1%

Median survival time Is 10,4 month (95% ,8,8-12).

1-year sun/lval rate Is 34,7%.2-year sun/lval rate is 6,7%.

Side effects were not significant and short- long.

None of the patients were stopped treatment due to side

effects.-

Keywords: Hanoi Oncology hospital, Paelitaxel￾earboplatin

DAT VAN D^

Ung thu phdi (UTP) Id bpnh ly dc tinh thudng gap

nhat va la nguyen nhdn tir vong hang dau do ung thu d

nhieu nude tren th i gidi. Cf Vipt Nam, ggp hdng dau d

nam gidi vd thir 3 trong cde UT d ntr gidi [2].

Theo phdn logi ciia To chu'c y t l th i gidi, UTP dupe

chia Idm 2 nhdm chinh Id ung thu phdi khdng phai t l

bdo nhd (UTPKPTBN) va ung thu phdi f l bdo nhd

(UTPTBN), trong dd UTPKPTBN chilm 80 - 85% [5],

LE THU HA

Benh vien Ung Bw&u Ha Ngi

Hda chat Id phuong phdp thudng dp ddng d giai

doan muen. Paditaxel Id mpt Taxan ed hieu qua ro ret

trong dilu trj UTP khdng phai te bdo nhd giai doan

mupn, khi ding don dpc hay phdi hpp Carboplatin - th i

he 2 ciia hpp chdt platin. Do nhung hieu qua va tinh an

todn dd dupc chirng minh qua nhilu thir nghiem Idm

sang, phdc dd Palitaxel - Carboplatin dd trd thdnh mot

trong nhtrng phac dd dupc sir dyng rpng rdi nhit tren

t h i gidi , dgc biet d My.

Chiing toi tien hanh nghien cu'u nay Tai benh vien

Ung budu Ha npi vdi hai muc tieu: Danh gia hieu qua

phic do Palitaxel - Carboplatin trong diiu tri

UTPKPTBN tpi bpnh vien Ung Buou Ha Ngi (2006-

2009) va tic dung phy cua phac dd

OOI TUONG vA PHl/ONG PHA P NGHIEN CLfU

1. 061 tir o'ng nghi en ciru:

Gom 45 BN ung thu phdi khdng phai t l bdo nhd giai

dogn lllb, IV dupe dieu tri bdng hda chdt phdc dd

Paditaxel + Carboplatin tgi benh vien Ung budu Ha Npi

tU' thdng 1/2006 di n thang 8/2009.

Tieu chuan lya chpn:

Chan dodn Id ung thu phdi giai dogn IIIB-IV

Chan dodn md bpnh hpe Id ung thu phdi khdng

phai t l bdo nhd. Kanofsky > 70.

Khdng mde ung thu thu' 2.

Chua dieu tri bdng cac phuong phdp tgi chd hay

todn than trudc dd.

Khong cd chdng chi dinh dieu tri hda chat

Dilu tri tdi thiiu 3 dpt hod chat.

Chap nhgn tham gia nghien ciru.

Cd hd so luu tru day dii. 2. Phirong phap nghien cii'u

2.1. Thilt k l nghien cu'u: Md ta tien ciru vdi co

mau thugn tipn

2.2. Thu thdp thdng tin: Thu thdp thdng tin theo

mau bpnh an nghien eiru.

3. Cac budc tiln hdnh:

3.1. Danh gia lam sing, cpn lam sang trw&c dieu

trj

3.2. Dieu tri hoi chat phic do " Paditaxel

Carboplatin":

1. Paditaxel: 175mg/m^ da truyln tTnh mgch ngdy

1 (trong 3 gid)

2. Carboplatin: 300mg/m^ da truyln tmh mgch

ngdy 1 (trong 21 ngdy)

3.3. Oanh gid hieu qud dilu trj vd tdc dung phu

4. Phdn tich vd xir ly sd lipu

* Cdc thdng tin thu thap dupc ma hoa va xir ly tren

phan mi m SPSS 16.0.

* Phan tich thdi gian sdng them theo phuong phap

Kaplan -Meier.

* Cac thugt toan thdng ke:

KET QUA NGHIEN CQU

Dgc diem bpnh nhan trong nghien ciru

V HOC THl/C HANH (755) - SO 3/2011 51