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Nguyen Van Tu vd Dtg Tap chi KHOA HQC & CONG NGHE 101(01): 127- 131

NGHIEN CUXI TAN XLAT KHANG NGUYEN MOT SO NHOM MAU

TAI TRUNG TAM HUYET HOC TRUYEN MAU THAI NGUYEN

Nguyen Viln Tu, Nguyen Kieu Giang, NfiuyCn TiCii Dung

Inrong Dai hgc ) Dian - DII Thai \giiyen

TOM TAT

Qua nghien ciru khang nguyen nhom mau cua 5 12 ngudi hi^n mdu va hoc sinh cac trudng dan toe

ngi Irii Bac Kan, Tuyen Quang, Thfii Nguyen, chimg toi da thu duoc k^t qua nhu sau. ly le cac dan

igc linh iheo l6ng s6 nguoi duoc xai nghiem 1^ dan tgc Kinh 28,7%, Tay 20,5%, Nung 12,3%,

Dao 12 7%. Mudng 12,7%, khiic 13.ro Cac khang nguyen D.k,Lub,s gap vdi l^n xudl 100%,

khang nguyen S gSp voi t^n xudl thip la 6,8%,. khiing nguyen K. Lua khdng gflp Kieu hinh he Rli

Dee gap nhieu nhai voi 57.07"o. kieu hinh DCcL gSp il nhit vdi 0,7% Gap kieu hlnh he Kell \ii

K-k- la 100%, Kieu hinh Fy(a+b-) 86,1%. ki^u hinh Fy(a-b+), Fy(a-b-)l 4'1<> Jk(a+b+) 41,1%,

Jk(a-b-) 5,6, Le{a-b+) 65.5%, Le(a+b-) 4,3% Lu(a-b-i)100% M+N i 57%, M-N- 0%, S-s+ 93,2%,

s-0%. S gap 6,8%

Til' khoa: nhdm mduph'inoty-pe

DAT VA N D E

Nhdm mau he hdng cau ffdng vai tro rat quan

trgng trong thuc hanh truyen mau. Theo cdng

bo ciia Hdi Truyen mau quoc te den nay

ngudi ta da nghien cuu va phat hien dugc 30

he nhdm mau hdng cau vci khoang 325 khang

nguyen khac nhau [ 1 ], [4]. [5], [6], Do vay, de

lua chgn dugc mgt do'n vi mau hoan toan phii

hpp vdl benh nhan ve tat ca cac he nhdm mau

la viec khdng de thuc hien. Tren thirc te, van

gap nhirng tai bien truyen mau do trong huyel

thanh ciia ngudi nhan co nhUng khang the bat

thu'dng chdng lai cac khang nguyen co tren be

mat hdng cau ciia ngudi cbo.

De han che dugc nhCrng tai bien truyen mau.

hien nay tren the gidi da trien khai va thuc

hien mgt each triet de cac xet nghiem dam

bao an toan truyen mau ve mat mien dich

nhu: dinh nhdm mau he .'iBG, Rh va mpt so

he nhdm mau khac ciia ca ngudi cho va ngudi

nhan; thuc hien phan irng hda hgp day dii va

sang loc kbang the bat thuong cho ca ngudi

cho v^ ngudi nhan tir nhieu nam nay. Mdt sd

nu'dc da truyen mau hdu hpp phenotype cho

benh nhan dupe truyen mau nhieu lan [9.10]

Tai Viet Nam, hicn ne) ky thual sang loc

khang the bat ihirdng cho ca ngudi cho mau

va nhan mau moi dugc thuc hien tai Vien

Huyel hgc - Truyen mai Trung uang; mgt sd

trung tam Idn khac chi thuc hien cac xet

nghiem nay cho ngudi nhan mau. Nh u vay.

Tel 0913 516863

viec thuc hien cac xel nghiem bao dam an

loan truyen mau cdn chua day du va viec thgc

hien an loan truyen mau la chua triet de [I, 2,

3, 4. 7. 8].

Do dd, nghien ciru tan suat xual hien cac

khang nguyen hdng cau o' ngudi hien mau

nhdm O de xay dung panel hdng cau sang Igc

va dinh danh kbang the bat thudng mang tinh

dac thil ciia ngudi Viet Nam va tien tdi truyen

mau hda hgp phenotj'pe eho benh nhan

thalassemia va benh nhan nban mau nhieu lan

la rat can thiet. Vi vay, chimg lot lien banh de

tai nay nham muc tieu.

Xdc dinh nhom mdu vd kieu hinh nhdm mdu

cua he Rh(D.C,c,E,cj, Kell Kidd Duff): f.eu-is.

Lutheran. PI. M\'Ss cua ngirdi hien mdu vd

hoc sinh cdc Inrang dim Igc noi tru Bdc Kan,

Tuyen Quang, Thai Nguyen

DOI TUONG VA PHUONG PHAP

NGHIEN CU'U

Doi tufcng: 512 ngudi hien mau va boc sinb

Trudng dan tgc ndi tni Bac Kan, Tuyen

Quang, Thai Nguyen.(nhdm mau O)

Phuong phap nghien cuu: md ta cat ngang

- Dmh nhdm ABO bang phuong phap

HTM,HC M

- Dinb nhdm Rh (D,C,c,E,e) bang gelcard ciia

hang Diamed (Thuy Sy )

- Dinh nhdm Kell. Kidd, Duffy'. Lewis.

Lutheran, MNSs. PI b^ng PP ong nghiem, sii

dung KT don ddng monoclone antibody ciia

hang CE (Dire).