Nghiên cứu sự thay đổi về hình thái và số lượng của khối tiểu cầu máy được tách từ một người cho trên máy tự động

TCNCYH PhtJ trWdng 62 (3) - 2009

Summary

CLINICAL SPECTRUM AND BIOLOGY CHARACTERISTIC

OF GLANZMANN THROMBASTHENIA (GT)

Ojectives: study some clinical and biology chacracteristics of Glanzmann throbasthenia. Methods: a

retrospective and perspective describe study of 27 patients with Glanzmann thrombasthenia. Results:

average age is 5.97± 1.97, male/female ratio = 2.3. Beside hemorrhagic pattern of platelet disorders,

patients with GT often admitte to hospital due to epistasis or other mucous bleeding. Hemorrhragic

severity with grade I acounted for 16/27 children, and grade 111 acounted for 11/27 patiets. Prolong

bleeding time, no normal clot forms, serious decreased platelet aggregation to ADP and collagen but

normal to ristocetin, normal platelet count, APTT, PT and Fib are charateristic to GT. 12/19 patients with

anemia are microcytic and hypochromic. Conclusions: GT often admitte to hospital due to epistasis or

other mucous bleeding and serious decreased platelet aggregation to ADP and collagen but normal to

ristocetin are charateristic to GT

Keywords: Glanzmann thrombasthenia, platelet aggregation

NGHIEN CLfu SU" THAY DOI VE HIN H THAI VA SO LU'ONG

CUA KHOI TIEU CAU MAY DU'CSC TACH TL/ MO T NGJOU CHO

TREN MAY TU DONG

Vu DiJc Binh, Bui Thj Mai An

Vien Huyet hgc Truyen mau Trung dang

Nghien cdu sU thay ddi ve hinh thii vi sd luang cua tieu ciu de biet dugc chai lugng vi sd lugng cua

tieu cau trong qui trinh bio quan trUdc khi truyen cho bdnh nhin li rat can thiet. Muc tieu: nghien cdu sU

thay ddi ve hinh thii va sd lugng ciia tieu ciu trong khdi tieu du miy dugc tich td mdt ngUdi cho tren miy

tit dgng Hemonetics vi Cobe Spectra. Boi tUgng va phuang pbap ngbien cdu: stt thay ddi ve hinh thii tieu

cau bang kinh hien vi didn td tia quet vi dem sd lugng tieu ciu bang miy dem te bio ttt ddng Sysmex - SE

3000 trong 20 khdi tieu ciu miy dugc tich td mgt ngudi cho tren miy tU dgng Hemonetics (10) vi Cobe

Spectra (10). Ket qua va ket luan: sd luang vi hinh thii cua tieu ciu trong khdi tieu ciu deu cd sU thay ddi

sau 1, 2, 3, 4 vi 5 ngay bao quan. Sd dung khdi tieu ciu di bao quin lau ngiy cd the anh hUdng den bleu

qua dieu trj benh nhan.

Tii khoa: khdi tieu cau, so Ifldng cua khdi tieu cau, kinh hien vi dien tuf

I. DAT VAN DE truyen cho benh nhan la rit cl n thiit. De tim

hieu sd' Ifldng cua TC da cd mdt so tac gia di slu

Nghien cflu sfl thay ddi v l hinh thai va sd nghien cflu, viec nghien cflu sfl thay ddi c l v l

lflpng cua khd'i tieu cl u (KTC) may tach tfl mdt hinh thai va sd Ifldng TC trdng qua trinh bao quan

ngfldi cho de bil t dfldc chit lifdng va sd lfldng cua thi chfla cd tac gi l nao tai Viet Nam nghien cflu

tiiu cl u (TC) trong qui trinh bio quin trfldc khi [1, 2, 5]. Do vay, chung tdi tien hanh d l tai nay

29