Nghiên cứu sự thay đổi lâm sàng và một số chỉ tiêu miễn dịch ở bệnh nhân viêm mũi dị ứng điều trị miễn dịch đặc hiệu đường tiêm tại Hải Phòng

AST mpt each ddng ke. Ndng dp AST vd ALT giam

ed y nghTa thdng ke vd'i p<0.01 (Bang 1). Nhan xet ve

dap LPng cua ALT sau dieu tri Fortec 1 thdng ehiing

tdi nhdn thiy: 63,3%) sd benh nhan sau khi dieu tri ed

ALT trd ve binh thuong hoac giam >75% va 20%i sd

benh nhdn cd giam tu' 50-75%) (Bang 2, bieu dd 2).

Nghien ciru cua Jung, Choi vd cpng sy tren 46 BN

viem gan, cdc tac gia nhan thiy miPC dp giam ALT Id

61%) d thdng thir nhat, 65%) d thdng thip 2, 83-97%) d

thang thir 3 va thir 4 [trich 2]. Mpt nghien CLPU khde

tai Han Qudc tren 95 BN viem gan, cdc tac gia cung

dat dyge 63.6%) BN viem gan giam ALT cd y nghTa

thdng ke d thdng thif nhat vd 80.8% d thdng thip 2

[trich 4]. Nghien CLPU cua Qudch Thanh Lam tren 42

trud'ng hgp viem gan man dung Nissel tdc gia dat

dygc ty le ddp irng hodn todn cao hon chung toi

81.8%), ddp LPng mpt phin 50%i vd 9% khdng dap

ifng [1] . Mifc dp dap irng hoan toan cua chiing tdi

thip han so vd'i tdc gia Qudch Thanh Ldm vd cpng

sy. Sy khac biet ndy cd the Id do tryd'C khi dieu trj

ALT d benh nhan cua chung tdi Id 281,56 ± 317,63

eao han so vdi ALT d benh nhdn cua Qudch Thanh

Ldm la 198,46 ±124,06. Nghien CLPU cCia Lee tren 66

BN viem gan man cung nhan thiy cd sy cai thien rd

ret cua BDD tren trieu chipng lam sang vd AST, ALT

[3].

Chiing tdi khdng nhan thiy cd sy thay ddi ve

Protit, albumin mau va ty le Prothrombin d nhdm BN

diing Fortec lOOmg/ngdy* 4 tuan. Ndng dp Bilirrubin

huyet thanh cd giam tuy nhien sy khde biet khong cd

y nghTa thdng ke. Mot sd nghien CLPU lai eho thiy

diing Fortec dat dygc 80%i BN cd ndng dp Bilirubin

mdu cao trd ve gidi han binh thyd'ng, 5% ed cai thien

va 15%) khdng ddp ipng sau dieu tri [trich 5]. Nghien

eifu eua Qudch Thanh Lam cung nhan thiy: cdc ehi

sd khde ve sinh hda nhu Bilirubin huyet thanh.

Albumin, globulin cdc chi sd Hong du . Bach d u va

Tieu clu deu khdng cd sy thay ddi sau dieu trj [1].

Jung cung nhdn x6t: Protein, Albumin mdu vd

Bilirubin khdng thay ddi sau dieu tri BDD [trich 2].

Chiing tdi khdng nhdn thiy tdc dung phu cd y

nghTa ndo trong qud trinh dieu tri Fortec, 2 BN xuat

hipn chdng mat budh ndn nhung tdc dung phu ndy

mit di nhanh chdng. Nghien eCfU eua Qudch Thdnh

Ldm vd eac tdc gia Han Qudc cung dua ra nhan xet

tuong ty [1.2.3]. Nghien cCfu tren 328 BN dung

Fortec, cdc tdc gia nhdn thiy khdng phdt hi$n tdc

dung phu ndo, trif mdt vdi truang hap budn ndn nhe

[trich 5]

K^T LUAN:

4 tuan dieu trj bang fortec d benh nhan viem gan

cho thiy thudc cd tdc dung Idm giam cdc trieu chipng

CO nang nhu: Met mdi, chdn an, dly chuccng bung,

mat ngu va dau viing gan, ddng thai thudc ed tdc

dung Idm giam manh ALT vd AST trong mdu.

TAI LIEU THAM KHA O

1. Qudch Thanh Lam vd cpng sy (2004): Dilu trj

viem gan sieu vi man tinh vdi Nissel kit qua theo ddi

sau 1 nam. Y hgc thanh pho Ho Chi Minh tap 8 phu ban

so 1. trang 23-30.

2. Abdel-Salam OM, Sleem AA, Morsy FA et al

(2007). Effects of biphenyldimethyl￾dicarboxylate administration alone or combined with

silymarin in the CCL4 model of liver fibrosis in

rats.Sc/enr//7c Worid Joumal.,7:1242-55

3. Hyo-Suk Lee., Yong Tae Kim, Hyun Chaee Jung

et al (1991), Prospective, randomized, control trial with

Diphenyl dimethyl dicarboxylate in chronic active liver

diseases: The effect on lowing serum, alanine

aminotransferase level. The Korean joumal of Internal

Medicine, Vol 40, No 2, 1991,172-178.

4. Saw^ SA, Shafey AM, Bahrawy HA et al (2002).

Effect of dimethyl diphenyl dicarboxylate on normal and

chemically-injured liver .East Mediterr Health J.8(1):95-

104.

5. Gao M, Zhang J, Liu G et al (2005). Effect of

diphenyl dimethyl dicarboxylate on eoneanavalin A￾induced liver injury in mice. Liver Int. 25(4):904-12

NGHIEN CUU Sir THAY DOI LAM SANG VA MOT SO CHI TIEU MIEN DjCH OT BENH NHAN

VIEM MO I Dl UfNG DIEU TRI MII N DICH DAC HIEU DO&NG TIEM TAI HAI PHONG

TOM TAT:

Daf van de: Diiu tri Viem mui dj irng (VMDU) theo

ca chi benh sinh hay lieu phap miin djeh (LPMD) co

hieu qua va kinh ti han han cac phwang phap diiu tri

khac. IVIuc tieu: Danh gia hiQU qua lam sang VMDU' do

Denvatophagoides pteronyssinus (Dp) sau dieu tri

LPMD dwang dwai Iwai va nghien ciru sg thay doi mot

so chi so c$n lam sang sau dieu trj. Doi twgng va

phwong phap nghien cii'u: Gom 40 b^nh nhan chan

doan VMDW vol Dp, nghien ciru tiin ciru, tw doi chimg

tai Benh vien DHY Hai phong. Ket qua: Tuoi tmng binh

34,25 ± 6,4, nhom tuoi 16-29 chiim ty le cao nhat 40%,.

TRAN THAI SON, PHAM VA N THCTC,

PHAM QUANG HOAI, PHUNG CHI THIEN

Sau diiu tri cac trieu chimg lam sang diu giam, trieu

chimg hat hai giam nhiiu nhit 72,5%,. Ham Iwgng IgG

tang, test lay da, phan irng tieu bach cau dae hieu, ham

Iwgng IgE diu giam so vai trwoc diiu trj co y nghia

thing ke. Ket luan: Diiu^ trj VMDU do Dp bang LPMD

dwang tiem cho kit qua tot, kha: 70%,, tmng binh 22,5%,

kem 7,5%,.

Tir khoa: Viem mui di img, lieu phap miin djeh

Resume:

Introduction: Rhinite allergique traitee soil par le

mecanisme physiopathologique, soil par /'

16 Y HOC THirC HANH (727) - SO 7/2010