Vai trò Toll - Like Receptor trong đáp ứng miễn dịch

TCNCYH 70 (SJ - 2010

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VAI TRO TOLL-LIKE RECEPTOR TRONG DAP L/NG MI§N DICH

The role of Toll - like receptor in immune response

Pham Dang Khoa

TrUdng Dai hoc Y Ha Ndi

Bio vg tfnh toan ven eua cd the la mdt thude

tinh eua tat e l mpi loai sinh vaL tfl loai giln don

(sinh vat ddn bao) dg'n loai eao cap (dpng vat cd vd

va ecn ngfldi). Dap flng miln djeh la mot phflpng

thdc quan trpng gidp mpi loai sinh vat bio ve dflpe

tinh toan ven eua ed thi , thdng qua viec loai bd

eae yg'u td la (khang nguyen) da xam nhap.

D i p dng mil n djeh dflpc phan bigt 2 dang:

- Dap flng mil n djeh khdng dae hieu (hay dap

flng miln djeh bam sinh, di p flng mil n dich tU

nhign) la di p dng mil n dich mang tfnh sin cd,

tfnh di truyin va khdng ein qui trinh mi n dm .

Dap flng nay xuat hign trflde trong bae thang tig'n

hoa eua sinh gidi.

- Di p dng mil n djch dac hieu (bao gdm mil n

djch djch the v l mil n djeh te bao) la ki t qui eua

qua trlnh mi n dm .

Trong sud't mdt thdi gian dai, di p dng mien

djch dac hieu dflpc tap trung nghien cflu nhilu va

thu dflpc nhflng hieu big't phong phd, dang ke.

Trai lai, di p flng mil n dich khdng dac hieu ft

dupe quan tam nghien cflu va sfl hieu big't chi

dflng lai d chdc nang eua 4 hang rao: vat li, hoa

hpe, tg' bao va eo dja. Tfl khi phat hien hg thdng

Toll-like receptor, sfl hilu big't v l tam quan trpng

cua mien djch khdng dac higu cd nhflng bflde tiln

to Idn, gidp ehdng ta hieu rd hdn ve cd eh i nhan

bie't khing nguyen eua mil n dich khdng dac hieu.

1. Dai cOdng ve Toll-like receptor

Nhflng nghien eflu v l he thdng de khang eua

vat ehu d loai rudi giam (Drosophila) da cung cap

nhflng hieu bil t di u tign v l ed che' nhan bie't

khang nguygn cua mil n djeh khdng dae hieu. 6

loai rudi gia'm, mpt hp Toll receptor ddng vai trd

quan trpng trong eupc ehie'n da'u chdng lai sfl xam

nhap cua eae yl u td gay benh. Sau dp, d e

receptor tfldng tfl nhfl Toll receptor d rudi giam da

dflpc nhan bie't d dpng vat ed vu va chung dUde

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