Nghiên cứu tỷ lệ động vật có vết thương phần mềm bị nhiễm chất độc dielodietylsulfid, clovinyldieloasin sống sót ở các nhóm được điều trị bằng các phương pháp khác nhau

thiit tham dd cdc diim khde nhau, tde gia phdt hipn vin

cdn thay t i bdo ung thu tren dien cat thyc quan (48,1%),

mac du trong tat ca cdc trirong hpp ndy lue mo phiu

thuat vien ghi nhdn:"sd thay thyc quan mim", v i phia

dudi u cdng xa u thi t l bdo ung thu cdng it di vd din

6cm thi khdng thdy t i bdo ung thir nira. Nhu- vdy, d phia

tren chiing ta can lam sinh thiit tire thi tpi mdm cat thyc

quan din khi eho kit qua dm tinh, mdi dam bao mdm

cat khdng cd t i bdo ung thu. 0 phia dudi cat dudi u

hon 6cm thi dam bdo bd an todn, ti le cat dupc u Id

83,1%, chu ylu Id cat todn bd da ddy don thuan qua

dudng bung, thdi gian sdng them sau md trung binh

nhdm cat dupe u Id 13 thdng, nhdm khdng cat dupe u Id

7 thdng[4].

Cdc nhd ngoai khoa Nhdt ban: Theo Katai. H vd

cpng sy, nghien ciru 128 benh nhdn, cdt eye tren da

day dilu tri ung thu sdm 1/3 tren dp ddy eho kit qua rat

tdt 90,5%, sdng sau 5 ndm vd ti Ip tdi phdt Id 0,8%. Tde

gia, Shinohara. T vd cpng sy, nghien ciru, eat phanJren

dp ddy bao tdn tdm vj eho nhirng khdi u da ddy sdm 1/3

tren, cd bd dudi 2cm tir dudng tdm vj -thyc quan, giam

trdo ngupe thyc quan. Tanimura. S vd cpng sy, thyc

hipn cdt todn bp dp ddy vd cat eye tren da ddy, vet hach

Dl, D2 bang phdu thudt ndi soi eho ung thu da ddy sdm

1/3 tren mang Ipi kit qua tdt vdi 110 benh nhdn, ti le tdi

phdt Id 0,9%[8]. , ,

K^TLUAN

I.Ung thu vj tri 1/3 tren d? ddy thudng ehan dodn

mupn, dau hipu ldm sdng gpi y nudt nghpn 85,36%.

Nhd vdo npi soi dp ddy, chyp thyc quan-dp ddy can

quang, sieu dm byng, chyp cat Idp vi tinh chan dodn xdc

djnh vd phdt hipn di can xa.

2. Phau thupt cdt eye tren dp ddy cho nhOng khdi u

gpn <4cm vd cat todn bd da ddy cho nhQ'ng khdi u >4em

khu trii thdnh da ddy, kit hpp vet hach. Khdi u xdm Idn

td chire xung quanh, di cdn xa, khdng cdt bd dupe thi

md thdng da ddy nudi duong hode dat endoprothese.

TAI LIEU THAM KHAO

1. Le Mpnh Hd (2004), Kit qua budc ddu dilu tri ung

thu da ddy,Y hpc Vipt Nam sd ddc bipt, 85-90.

2. Hd Van Quylt (2008), Nghien ciru ung thu da ddy

sdm chan dodn, tdn thuong GPBL vd kit qua diiu tri

phdu, ngoai khoa sd 6, 19-28.

3. Dd Van Trdng, Trinh Hdng Son (2009), Kit qua

budc ddu nao vet hpch bang phau thudt ndi soi trong

diiu tri ung thu da ddy vung hang mdn vj, Y hpc thyc

hdnh sd 1, 11-14.

4. Do Du-c Vdn (2002), Ung thu tdm vj: cd nen thay

ddi thdi quen trong cdch lya chpn phu'ong phap md, Ky

yiu todn vdn cdc dl-tai khoa hoc. Tap chi ngoai khoa

20-28.

5. Ldm Thj Vinh (2004), Nghien ciru dae dilm Idm

sdng vd npi soi ung thu da ddy tai benh vien trung uong

Hui, Y hpe Vipt Nam sd ddc biet, 102-105.

6. Elwyn. C (2007), Ung thu da ddy, Thdng tin y

khoa, www.thongtinykhoa.com 1-18.

7. Desai. A. M et al (2004), Improving outcome in

gastric cancer over 20 years. Gastric Cancer, 7, 196-

203.

8. Katai. H et al (2010), Long-term outcome after

proximal gastrectomy with jejunal interpositison for

suspected eariy cancer in the upper third of the stomach,

British journal of surgery, 97, 558-562.

NGHIEN CUU TY LE DONG VAT CO VET THUt^JG PHAN MEM

Bj NHII M CHAT DOC DICLODIETYLSULFID, CLOVINYLDICLOASIN

SONG SOT or CAC NHOM DimC DIEU TRI BANG CAC PHITONG PHAP KHAC NHAU

TOMTAT

T^ le chugt nhit tring song sdt d nhdm cd vit

thuang (VT) bj nhiem ddc dielodietylsulfid (DCDS)

hoic clovinyldieloasin (CDA) deu thap han so v&i

nhdm chugt bj nhiim dgc qua da lanh va nhdm cd VT

khdng bi nhiim ddc.

Tieu ddc VT bi nhiim DCDS d thdi diim 2 phiit

hoic cit Igc VT d phiit thU 30 sau nhiem ddc deu lim

ting t^ le ddng vat song sdt. Nhdm chugt dugc dieu

tri phdi hgp vifa tieu ddc, cit Igc vita bdi VT bing kem

Herbavera cd t^ le song sdt cao han nhdm chi cit Igc

dan thuin. Tieu ddc VT mudn d phut thU 30 sau

nhiem ddc, fj? le ehudt song sdt thay doi khdng cd y

nghTa thong ke so vdi nhdm khdng dugc dieu tri.

Tieu ddc VT bj nhiem CDA d tiidi diim 2 phiit

hoic cit Igc VT d phut thU 10 sau nhiim ddc deu lam

ting t^ le dgng vit song sdt. Nhdm chugt dugc dieu

TRAN VA N TUNG, HOANG CONG MINH

Trung tam phong chdng nhiem dpc, HVQY

trj phoi hgp vifa tieu ddc, cit Igc vda bdi VT bing kem

Herbavera cd t^ le song sdt khdng khie biet so vdi

nhdm chi cit Igc hoac tieu ddc dan thuan. Tieu ddc

VT bi nhiem CDA mudn d phiit thU 10 sau nhiim ddc,

khdng lam tang dugc fj? le chugt song sdt.

* Td khda: dielodietylsulfid, clovinyldieloasin, vet

thuang phan mem, t^ le ddng vat song sdt.

SUMMARY

The rate of survival of the mice with the soft

tissue wound exposed by dichlorodietylsulfide or

chlorovinyldichloroarsine was lower than the group of

skin exposed and the group of unexposed soft tissue

wound.

Eariy decontamination of the wound exposed by

dichlorodietylsulfide at the 2"" minute or surgically

removing surface of the wound at the 30'" minute, the

rate of survival of the mice was increased.

Y HOC THl/C HANH (727) - SO 7/2010 71