Nghiên cứu phát hiện sớm tự kỷ bằng bảng kiểm sàng lọc tự kỷ ở trẻ nhỏ (MCHAT-23)

(23,4 , 7,5) va nhdm 2: (24,5 , 8,4), su khac biet khdng

ed y nghTa thong ke vdi (P > 0,05). 100% benh nhan d

ea hai nhdm elt sot sau 48 gid dieu trj.

Thdi gian sgch KSTSR trung binh (tinh theo gid) d

nhdm 1 la: (20 , 5,2), d nhdm 2 la: (21 , 6,7) su khac

bipt giua hai nhdm bpnh nhan khdng ed si,f khac biet vdi

(P^> 0,05). 100% bpnh nhan sgch KSTSR trong 48 gid

dieu trj.

Hieu li,>'c dieu trj khdi trong 28 ngay cua hai nhdm la

100% khdng cd su khac biet. Hipu luc dieu trj chong tai

phat xa sau 8 tuan dieu tq cua hai nhdm la nhu' nhau

khdng cd si/ khac bipt. (khdng cd bpnh nhan tai phat).

TAI LI$U THAM KHAO

1. Nguyen Mgnh Hong (1996), "so sanh hi$u Iwc hai

phic do dieu tri sot ret do P. vivax bang Chloroquine

tong lieu 1,5g va 2,5 g ket hQp vdi primaquine". Lugn

van thgc sy y hpc.

2. Bui Tri Cudng (2006), "Nghien cuv du^c dpng

hgc kha nang dung nap cOa primaquine lieu cao tren

nguui tinh nguyen va hieu Iwc dieu tri sot ret do P. vivax

bing Artesunate phoi hQp vdi primaquine" Lgn an tien sy.

3. Doan Hgnh Nhan (1996), "Hieu qua dieu tri

chloroquine vdi b$nh nhan P.vivax a mgt so dj diem

nghien cuv", Tgp chi y hpc thifc hanh. So 8, trang. 6-13.

4. Tgp Huan Dieu Trj Sot Ret (2005), Phdng chong

va dieu tri bpnh sot ret, Vien Sot Ret - Ky Sinh Trung -

Cdn Triing Trung Lfang, trang 8 - 26.

5. K.M.B. Ajdukiwicz, E.L.C. Ong (2007),

Management of vivax malria with low sensitivity to

primciQulne. Journal of infection 54, 209-211.

b. Jaird JK, Basri H et al, (1994), In vivo test for

resistance to chloroquine by Plasmodium vivax Program

and abstracts of the 43^" annual meeting of the American

society of Tropical medicine and Hyg Vol 51.

, y

na'it ... NGHIEN ClAJ PHAT HIEN SOM TlJ KY

BANG BANG KIEM SANG LOG TlT KY OTTRE NHO (MCHAT- 23)

T6M TAT

Miic tieu: Phit hien sdm tw ky bang Bang kiem sang

Igc twky (MCHAT- 23) & tre 18-24 thing tuoi va ud>c tinh

ty 1$ hign mic tw ky d tre 18-24 thing tuoi tgi tinh Thii

Binh. Phwortg phap: Nghien cuv mo ti cit ngang. Doi

twryng: 6.583 tre tuoi td 18 den 24 thing du^c sinh ra td

1/3/2007 den 30/3/2008 tgi 66 xa thugc 2 huygn cue tinh

Thii Binh. Ket qui: Ty 1$ trd cd ket qua bat thirdng vdi 4

ciu then chgt cao: 93,3% tre khdng dung ngdn tay tro dS

chi hoic the hign sw quan tSm den do vgt (Ciu 7);

86,7% tri khdng bao gid mang do vgt den khoe v&i bgn

hogc cha mg (Ciu 9); 80% tre khong dap ung khi duv'c

ggi ten (Ciu 14): 73,3% tri khong nhin vao do v$t/ dS

chai d mdt vj tri khic trong phong khi ta chi tay vao (Ciu

15). Bing kiim MCHAT- 23 li bd cdng cu cd dg nhgy

cao (74,4%) vi dg dgc higu cao (99,9%) tmng vigc phit

hi$n sdm tw ky a dg tuoi tdi 8 den 24 thing. Ty Ig hign

mic tw ky d tri 18-24 thing tuoi la 0,59%. Ket lu$n:

Sing IQC tw ky d tre 18-24 thing tuoi bang Bang kiem

MCHAT-23 tgi Thii Binh phit hign thay ty Ig hign mic tw

kyli0,59%.

TCr khda: Twky, sing Igc, phit hign sam.

SUMMARY

STUDY ON EARLY DETECTION OF AUTISTIC CHILD BY

USING MODIFIED CHECK LIST AUTISM IN TODDLE (M￾CHAT 23)

Objective: To eariy detect autism by using Modified

Checklist Autism in Toddle (MCHAT-23) among children

at the age range from 18 to 24 months old and to

estimate the prevalence of autism at that age range in

Thai Binh province. Methodology: Cross-section

descriptive study on 6,583 children homed during the

period of f Mamh 2007 - 30 March 2003 in 66

communes of 2 districts of Thai Binh province, Vietnam.

Results: The rate of children who have abnonnal results

in responding to 4 key questions is high: 93.3% of

NGUYI N TH! HUONG GIANG, TRAN TH| THU HA

Benh vign Nhi Trung uong

CAO MINH CH Au - TrUdng Dai hgc Y Hi n^l

chirdren don't use his/her index finger to point or to

indicate his/her interest in something (Question 7);

86.7% of children never bring objects to show you or

parents (Question 9); 80% of children don't respond

when calling his/her name (Question14); 73.3% of

chidren don't look at an object/a toy across the room

when you point at (Question 15). MCHAT-23 is a tool for

eariy detection of autism at the age range from 18 to 24

months old with high level of sensitivity (74.4%) and that

of specificity (99.9%). The prevalence of autism at the

age range from 18 to 24 months old in Thai Binh is

0.59%. Conclusion: Screening autistic child at the age

range from 18 to 24 months old by using Modified

Checklist Autism in Toddle (MCHAT-23) shows that the

prevalence of autism at the age range from 18 to 24

months old in Thai Binh is 0.59%.

Key words: Autism, screening, eariy detection.

DAT VAN D 6

Tl/ ky la mpt trong nhUng nguyen nhan gay khuyet

tgt d tre em. Tre bj mac tu ky khdng nhUng chgm phat

trien ve quan hp xa hpi, ngdn ngU, giao tiep, hpc hanh

ma cdn cd nhOng roi logn hanh vi anh hu'dng idn den

mdi tru'dng gia dinh va xa hpi.Ty Ip mic tu ky dang tang

len nhanh ehdng. Theo so lipu cua Trung tam Kiem soat

va Phdng bpnh Hoa Ky ty Ip mac tu ky tgi My la 1/150

(2007) va 1/110 (2009) tre sinh ra song [4]. Viet nam

ehua ed nghien cUu nao ve ty le mic tu ky. Tong so tre

dupe kham, chan doan xae djnh tu ky tgi khoa Tam

benh, B/v Nhi Trung uang tang len rd ret: 405 (2007);

963 (2008); 1.752 (2009). Tuy nhien ty le tre tu ky dupe

kham, chan doan bpnh sau 36 thang tuoi cdn cao

(43,86%) [1].

Tre tu ky neu dupe phat hipn sdm va can thipp sdm

se cd nhieu ca hpi (30%) phat trien binh thudng va hpi

nhgp xa hpi. Chinh vi vgy phat hipn sdm ty ky dang la

Y HOC TIH/C HANH (741) - SO 11/2010