Nghiên cứu hàm lượng pha viêm cấp tính (Protein C phản ứng và Procalcitonin) trong giai đoạn hoạt động của bệnh nhân Lupus ban đỏ hệ thống

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breast cancer (IBC) and benign lesions. Proc Int Soc

MagnReson Med. 1998;931

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7. Su MY,Cheung YC,Fmehauf JP,et al. Correlation of

dynamic contrast enhancement MRI parameters with

microvessel density and VEGF for assessment of angiogen￾esis in breast cancer J Magn Reson Imaging. 2003; 18:

467-477.

NGHIEN cunj HAM LUONG PHA VI£M CAP TINH (PROTEIN C PHAN UING VA PROCALCITONIN)

TRONG GIAI DOAN HOAT DON G CUA DINH NHAN LUPUS DAN DO HE THONG

T6M TAT

Mgc tidu: Bw&c dau nghidn ciru him Iwgng ciia pha

vidm cip tinh (Pmtein C phin img, vi Proealeitonin)

tmngaiai dogn hogt ddng eua bdnh nhin lupus ban dd

hg thong. D&i twgng vi phtrang phip nghien cuu: nghien

ciru md ti cit ngang, tiin ciru lim sing vi xdt nghigm

pha viem cap tinh eiia 48 bgnh nhin lupus ban dd hg

thong dwgc ehin doin vi diiu tq tgi khoa Ca Xwang

Kh&p bdnh vi$n Bgch Mai tw thing 6/2009 din thing

10/2010. Kit qui: 48 bdnh nhin lupus ban dd hi thong

ed tu6l tmng binh 38+14,5 v&i th&i gian mic bdnh tmng

binh 28,5+25,7 thing, tmng dd cd 21 b$nh nhin & giai

dogn 6n dinh bdnh (SLEDAI<5), vi 27 bdnh nhin & giai

dogn hogt ddng bdnh (SLEDAI>5). Him Iwgng pmtein C

phin ung nhdm bdnh nhin & giai dogn hogt ddng

5,38+4,35 mg/dl cao han hin nhdm bdnh nhin & giai

dogn 6n dinh bdnh 2,25+2,75ng/ml cd y nghTa thS.ig kd

v&i p<0,01. Him Iwgng ciia pmealcitonin tmng ci hai

nhdm: nhdm & gial dogn hogt ddng 0,114ng/ml vi & giat

dogn 6n dinh b$nh 0,052ng/m khdng cd sa khic nhau

ed y nghia thing kd (p>0,1). Kit luin: Tmng pha vidm

cip tinh chi cd him Iwgng CRP ting cd moi lidn quan

v&i giai dogn hogt dgng cua binh lupus ban do hi thing

Tir khda: Lupus ban do hi thing, proealeitonin,

pmein C phin img.

SUMMARY

INVESTIGATIONS THE LEVEL OF ACUTE PHASE

PROTEIN (C-REACTIVE PROTEIN AND PROCALCITONIN) IN

PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

DISEASE ACTIVITY

Objective: To study the level of C-reavtive pmtein

(CRP) and pmealcitonin (PCT) in patients with active

and inactive systemic lupus erythematosus who wem

diagnosed and treated in the Rheumatology department

Bach mai Hospital fmm 9-2009 to 12-2010

Patients and Methods: CRP and PCT was measured

in semm form 48 patients who fulfilled the ACR criteria

for systemic lupus erythematosus (SLE) treated in

Rheumatology department Bach mai hospital (fmm

June, 2009 to October, 2010). Disease activity was

measured using SLEDAI.

Results: 48 SLE patients with mean age 38+14.5,

disease duration 28.5+25.7 months. 21 SLE patients

with SLEDAK5 and 27 SLE with SLEDAI>5. CRP level

TRA N TH! MINH HOA

Khoa CaXifong Kh&p, Bgnh vi^n B^ch Mal

that were mart<edly elevated in SLE patients with active

disease (5.38+4.35mg/dl) compared with patients with

unaetive diease (2.25+2.75mg/dl) (p>0.01). No

correlation between the PCT concentrations in two SLE

gmup patients (0.114ng/ml and 0.052ng/ml) with SLE

activity dumtion.

Conclusion: CPR may serve as a useful marker for

the detection of activity diseases in patients with SLE

Key words: Systemic lupus erythematosus,

pmealcitonin, pmtein C reactive

DAT VAN Dt

Lupus ban dd hg thdng la mpt trong nhu-ng bgnh ty

miln tiay gap trong cae bgnh ly eo

xuong khdp vdi nhilu eo quan npi tgng bj tdn

thuang do sy ling dpng cua phuc hpp mien djch. Dien

biln cua b$nh lupus ban do he thdng ed cac giai dogn

vdi nhUng bilu hign lam sang, xat nghigm va ti§n lupng

khac nhau, giai dogn tiln triln bgnh (giai dogn hogt

ddng b$nh) va giai dogn dn dinh bgnh (giai dogn lui

b$nh). 0 giai dogn hogt dpng cua bgnh thudng bilu

hi$n tinh trgng lam sang rim rp d cac eo quan (sdt,

viim khdp viem da mang, tdn thuong than, thin kinh...)

do qua trinh viem va tang dap ung miln djch. Rit nhilu

nghien cuu [4,5,6,7] cho thiy pha viem d p tinh (acute

phase proteins) tang cao trong giai dogn hogt dpng ciia

bgnh va la mpt trong cac ylu to danh gia mue dp hoat

dpng va tien luang cua bgnh lupus ban dd hg thdng...

Pha viem d p tinh gdm mpt sd protein (protein C phan

ung-CRP, proealeitonin, haptoglobins, fibronogen, feritin,

bd thi C3, C4...) tang cao trong eae phan ung viem d p

tinh hoac mgn tinh, trin thuong, nhilm khuln elp tinh,

bdng, trin thuang, nhdi mau eo tim...[5,6,8] Cl vigt nam

da cd nhilu nghien cuu v l vai trd eua protein C phan

ung va proealeitonin trong qua trinh viem va tinh trgng

nhiem khuln eiia mpt sd benh ly [1,2,3], nhung ehua cd

nghien cuu nao v l vai trd eua protein C phan ung va

proealeitonin trong ddnh gi i mue dp hogt dpng eiia cac

bgnh ly ty mien ndi chung dgc biet la benh lupus ban dd

he thdng. Vi vgy, ehiing tdi tiln hanh nghien cuu d l tai

nay vdi mgc dich:

1. Khao sat ham lupng pha viem d p tinh protein C

phan irng va proealeitonin trong huylt thanh bgnh nhan

lupus ban dd hg thdng

2. Budc diu tim hieu vai trd cua protein C phan ung

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