Bước đầu đánh giá hiệu quả của test xanh Toludin (XT) để phát hiện tổn thương ác tính niêm mạc miệng tại bệnh viện Việt Tiệp Hải Phòng

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BUlDfC DA U DAN H GIA HIEU QUA CUA TEST XANH TOLUIDIN (XT) OE PHAT HIEN

TdN THU0NG AC TINH NIEM MAC MIENG TAI BENH VIEN VIET TIEP HAI PHONG

T6M TAT

td'ng dung test xanh toluidin, dung oratest tren: 31

tSn thuxmg viem, chung tdi cd nhgn xdt sau:

- Doi v&i 31 ca dirge chin doin lim sing vi GPB li

ung thu, phu hgp v&i lim sing, GPB li 100%,.

- Doi v&i 31 ca dirge chin doin lam sing li viem 8

tnr&ng hgp cho kSt qui test xanh toluidin (+), dd phu

hgp li 74,19%).

- Test xanh toluidin eho phdp xic dinh rd cic vi tri

tin thtrang kit qui btr&c diu cho thiy test xanh toluidin

li mdt phit hidn hd trg di phit hidn ung thu midng.

Tir khda: test xanh toluidin, oratest

THE UTILITY OF TOLUIDIN BLUE APPLICATION IN THE

DETECTION OF CANCER LESIONS IN VIET NAM - CZECH

HOSPITAL IN HAIPHONG.

SUMMARY

The application of toluidin blue test using oratest on

31 oral cancer lesions anh 31 inflammation lesions

issued the following remarks:

Positive staining was demonstrated in 31 lesions

clinically diagnosed as cancer and confirmed as so by

following histopatholigical examination with a

concordance rate of 100%,.

On 31 lesions cHnically and histopathologlcally

diagnosed as inflammation, toluidin blue test was

positive in 8 lesions, the concordance rate was 74.19%o.

Toluidin blue staining pmved to be a valuable visual

aid in detecting lesions. Preliminary results showed that

toluidin blue test in an effective diagnostic tool in the

detection of oral cancer

Keywords: toluidin blue test omtest

DAT VA N Oi.

Test xanh toluidin da dup'c nhilu tac gia tren the gidi

nghiSn cuu d l phat hign sdm ung thu niem mgc. Cf Vigt

Nam, Trin Thj Kim Cue, Huynh Anh Lan, Nguyen Thj

Hdng - Khoa RHM Dgi hpe Y Duoc Thanh phd Hd Chi

Minh da nghiSn cuu hieu qua cua test nay va cho thiy

PHAM VAN LI$U

Tnfdng D$i hgc Y Hii Phdng

test xanh toluidin la mdt x6t nghi$m hd trp d l phat hign

ung thu sdm niSm mgc mi^ng.

D l gdp th&m nhan xat, chung tdi thyc hi$n nghiSn

cuu nay tgi Bgnh vi0n Vigt Tigp H^i Phdng.

Vdi mgc tieu: Oanh gia higu qua eua test xanh

toluidin ddi vdi vige phat hien sdm tdn thuong ung thu

mieng.

061 TU'Q'NG VA PHU-aNG PHA P NGHIEN CLTU

Mau khao sat: 62.

Nhdm thii' nghiem: 31 gdm nhirng tdn thuong ni§m

mgc migng dufgc chin doan lam sang: K niem mgc

migng, nim vi$n.

Nhdm chung: 31 gdm nhirng tdn thuong niem mgc

migng dupe chin doan lam sang: vi6m niem mgc

mi§ng, ni m vign.

Phuong phap nghien cuu md ta elt ngang: diing

oratest.

Quy trinh chin doan:

- Kham lam sang eae bgnh nhan cd tdn thuong, lam

bgnh an, chin doan lam sang va phan logi tdn thuong.

- Cho bgnh nhan thyc hign test theo ehi dan ciia FDI.

+ Site migng vdi nudc 2 lln trong 20 giay.

+ Bdi tgi chd acid acetic 1% trong 20 giay.

-•• Bdi tgi chd 10ml dung dich xanh toluidin 10% tu 30

giay - 1 phut.

-•- Bdi tgi chd ll n 2 acid acetic 1 % d l rua sgch phim

mau dy.

-•• Sue migng Igi bing nudc.

- Ddnh gia ki t qua xet nghigm:

+ Xanh duong dgm, di u hay dgng ddm: Test duong

tinh.

+ Khdng bit mau hoge bat mau rit nhgt: Test am

tinh.

- Thyc hign sinh thilt va xet nghigm giai phlu benh.

K 6 T QUA:

62 ml u khao sat

31 tdn thifong dupe chin doan lam sang va giai

Y HOC THl/C HANH (751) - S6 2/2011 65