Tỷ lệ mắc hội chứng chuyển hóa ở người trưởng thành tại tỉnh Thái Bình năm 2009

TAP CHl NGHliN CO'U Y HQC

Summary

ASSOCIATION BETWEEN HYPERHOMOCYST(E)INEMIA AND

ATHEROSCLEROTIC VASCULAR DISEASE IN

PREDIALYSIS PATIENTS

Hyperhomocysteinemia is now recognized as an independent risk factor for atherosclerotic

cardiovascular disease in patients with normal renal function. Hyperhomocyst(e)inemia is

common in pafients with predialysis, but still unknown in Vietnam. This study was designed to

evaluate serum homocystein and look for an association between hyperhomocyst(e)inemia and

atherosclerotic vascular disease in patients with end-stage renal disease (ESRD). The result

indicated that plasma Hey level in prepafients was significantly higher in normal controls (26.39 ±

lO.ISpmol/L, 9.56 ± 1.92pmol/L) with p < 0.001. Whereas the median serum tHcy was

significanfiy higher in the pafients with thicker infima media (elM), the linear regression and

correlation is CIM = 0.02 + 0.01 * hey (r = 0.32; p < 0.5). In conclusion, there is an association

between hyperhomocysteinemia and atherosclerotic vascular disease in predialysis patients.

Prospective studies need to further examine the relationship between homoeyst(e)ine level and

atherosclerosis with chronic kidney disease.

Keywords: chronic kidney disease, Hyperhomocyst(e)inemia

TY LE MA C HOI CHLPNG CHUYDN HOA 6* NGU'O'I TRU'DNG

THANH TAI TIN H THAI BJNH NAM 2009

Nguyin Hodng Long\ Dd Dodn Lgi^, Nguyin Nggc Quang^, Le My^

'e<5 Y ti. 'Tmdng Dpi hpc Y Hd N0i

Ty lp mdc hdi ehung chuyin hod (HCCH) dang cd xu hwdng gia tdng d cdc nwdc dang phdt triin song

ehwa ed nhiiu nghidn cwu d Vipt Nam. Nghidn cwu nhim muc tidu xdc djnh ty Id hidn mic HCCH vd mdt so

yiu td lidn quan d ngwdi tmdng thdnh tpi tinh Thdi Binh. Kit qud cho thiy ty Id mic HCCH thay ddi tw 5,7%

theo IDF din 24,1% theo NCEP ATP III vd tdng din theo nhdm tudi vd chi sd BMI vdi hiu hit cdc tidu

chuin. Mdi lidn quan gida gidi vdi HCCH rit khde nhau theo tidu chuin chin dodn. Kit ludn: Ty Id mic

HCCH thay ddi rit idn tuy theo tidu chuin dwac dp dpng. Cin cd nhdng nghidn cwu, phdn tich sdu han vi

tidu chuin chin dodn HCCH phu hap cho cdng ddng ddn cw d Vidt Nam.

Td khoa: HOi chirng chuyin hod, ty 10 hiOn mdc, ti§u chuln chin dodn, ngud"! truang thanh

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djnh nghTa thdng nhit "HCCH Id mOt nhOm

Khdi niOm HOi eh&ng ehuyin hda dd duge ede rdi logn liOn quan di n chuyin hda cdc

bilt di n t& nh&ng ndm 1920 nhung di n chit bao gdm rdi logn lipid mdu. bOo bung,

nh&ng ndm 1980 cde fiOu chuln ehln dodn tdng huylt dp, rdi logn glucose mdu khi

eua HCCH van edn nhilu tranh cdi. Ndm ddi" [8]. Mdc dii vdy, hiOn van dang tdn tai

~20 TCNCYH 78 (1) - 2012