Thận trọng với thuốc giãn mạch glyceryl trinitrat

(k^ i^al

thudc giair mach

glyceryl trinitrat

Glyceryl trinitrat Id thule

gian maeh dung phd*

biln trong cdc bpnh tim

mach song do su gidn maeh thay

dli theo lilu lupng, dgng bdo ehl...

nfin ngfldi diing can co nhflng thdn

trpng cin thiit mdi dim bdo hifiu

qui, an todn.

SiJi gian mach thay doi theo

li^u li^tfng, dgng bao chl*

(j lilu trung binh, sU gian maeh

xdy ra chu yeu d tinh mgch, lam

giam lUtfng mdu ve tim (giam tiln

gdnh), kit qud Id gilm dp lUc trong

cdc budng tim, dong th&i cdn lam

gian mgch d cdc tilu ddng mach,

gidm sdc cdn ngogi vi d thi tam

thu va gidm tifiu thu oxy trong ctf

tim. Do phdn bo chgm, deu nen

thulc khfing gdy ha huylt dp dfing

maeh, khfing gdy nhip tim nhanh

phdn xa.

O lilu eao, thud'c gdy gian cdc

tilu dpng mgch, gilm huyit dp

ddng mach tuy khdng nhieu song

cfi th i gdy phdn xa giao cam lam

nhanh nhip tim.

> Dgng tdc dung nhanh:

Dang tifim, thulc chuyln hoa

rat nhanh tgi gan, ddo thdi qua

frDSCKII. BUIVANU Y

/Wdf thudc glyceryl trinitrat dang dan

thgn dudi dang ehit trung gian

(mono, dinitrat glyceryl), thdi gian

bdn huy chi 30 - 60 giay.

Dgng ngam dudi lfldi, thulc hap

thu nhanh, hoan todn, dat ndng dd

dinh chi sau 2 phut, ngim nhanh

vdo cdc ctf trtfn thdnh mgch gdy

hifiu lfle vd hifiu luc keo dai tdi

30 phut.

Dang phun mu, thufi'c dgt dfltfc

ning do dinh sau dfldi 5 phdt, giam

50% sau 3 - 4 phut.

Ba dang bdo che nay ed tde

dung nhanh thieh htfp cho dieu tri

cip cdu.

>Dgng tdc dung kio ddi: Sau

30 phut din 7 gid thud'c van tin

tgi ea dfldi dang chat chfla bifi'n D

- Thudc doi khdng thu thileucotrien: Cac thufi'c dfii

khdng thu thi leucotrien (monteleukat, pranlukat...)

dflng ngan chdn tdc dung cua leucotrien, mft hoat

chat trung gian dfldc phdng thieh ra trong qud trtnh

di flng gay vifim phe quan, nfin cd the dUde sd dung

trong dieu tri hen ph i quan do di flng. Tuy nhien,

chua ed ede tdi hfiu nghien cuU ehflng minh ve tinh

an toan cua nhiing thudc nay tren thai phu.

- Thuoc khdng histamin: Mac du thufi'c khdng

histamin khfing cd tdc dung trUc tilp dl dieu tri hen

THUOC & StfC KHOE so 512 (15.11.2014)

suyfin, nhimg ddi khi eung dupe sd dung dl dilu tri

cdc trieu chdng do di dng di kem, gdy kich phdt cde

con suyin.

• Nhiing thud'c khdng histamin th i h^ thd nhat

nhu diphenhydramin, chlorpheniramin co the gay

buon ngu; ngodi ra, cung cd thi gdy tdng m^t sl nguy

cd di tdt bam sinh khi dung trong thai ky.

• Cdc khang histamin the' he mdi htfn nhu

loratadin, cetirizin,,. ehUa dfldc thd nghiem day du

tren phu nfl mang thai. !$£