Nhận xét kết quả bước đầu trong điều trị ung thư mô đệm đường tiêu hóa giai đoạn muộn bằng Glivec (Imatinib) tại bệnh viện K

-—r__ '^^°^

TientrieiTXD)~-—-____ Tien trien trung binh 1 nam

Tien then trung binh 2 nam

Tien trien trung binh 3 nam

Tien then trung binh /nam

<2D

0,52

1,22

1,61

0,56

>2D

0,69

1,71

2,50

0,82

Tat ca 3 doi tupng deo kinh dwgc ddnh gid sau 1

ndm, 2 ndm vd 3 ndm cd ehung mpt quy luat Id d nhdm

hpe sinh cd sd kinh liie bat dau deo tren 2D thi di u tdng

nhanh hon nhdm ed sd kinh bdt dau deo dudi 2 D. Mue

tdng trung binh d nhdm bat ddu deo kinh vdi sd tu 2D

trd xudng Id 0,56D/ndm vd nhdm tren 2D Id 0,82D/ndm.

Theo nghien ciru eua Saw S.M, tiin triin d nhdm cd

muc can thj ban dau dudi 2D Id 0,56D/nam vd nhdm tu

2D trd len Id 0,65D/ndm, nhu vdy nghien cuu cua chiing

tdi cd nhdm can thj tren 2D tiin then nhanh hon, cd th i

do ehiing tdi Idy mdc tu tren 2D edn Saw S.M. tinh ca

BN tu can 2 D trd len.

Mpt sd tdc gia khde nhu Parssinen 0, Fan C S hay

Lam C.S cung ed nhdn xet Id mue dp can thj ban dau

cdng cao thi tiin then can thj edng nhanh.

Theo cua chung tdi thi nhdm ddi tupng xuat hipn can

thj (bat dau deo kinh) tru'dc 10 cd tudi ed mue tiin triin

can thj nhanh hon vdi sy khde biet cd y nghTa thdng ke

vdi nhdm tre xuat hien can thj sau 10 tudi, tuong ty kit

qua nghien cuu ciia Saw S.M.

Kit qua nghien ciru d bang 3.4. eho thay tiin triin

can thj nhanh nhat Id d nhdm 6-9 tudi (2,16D), khde biet

cd y nghTa thdng ke so vdi 2 nhdm khde tren 10 tudi

(1,89 vd 1,85D eho moi nhdm). Muc ndy ed chenh lech

ddng k i so vdi sd lieu nghien cuu cua Kartz J Id 1,28D,

cua Leung Id 1,23D hay cua Yang Id 1,5D.

Bang 4. Tien triin can thj theo tudi bat dau deo kinh

6-9

10-11

12-13

Trung

binh

2,16

1,89

1,85

SD

0,633

0,640

0,603

Thap

nhat

1,25

1,75

1,25

Cao

nhat

2,75

3,5

KET LUAN

- Mire dp tiin triin can thj trung binh trong 3 ndm Id

1,98D±0,61D.

- MLPC tang egn thj trung binh trong 3 ndm d nO' ego

hon nam (2,08 D so vdi 1,67 D)

- Nhdm bat dau deo kinh d dp 6-9 tudi ed tiin trien

egn thj nhanh nhat (2,16D/ 3 nam), chgm nhdt la nhdm

tren 12 tudi (1,85D)

- Muc dp egn thj lue bat dau deo kinh cdng eao thi

tiin trien egn thj edng nhanh. Nhdm bdt dau deo kinh vdi

sd tu 2D trd xudng cd muc tdng Id 1,61D/3 ndm va

nhdm vdi sd tu 2D trd len cd mue tang Id 2,5D/3 ndm.

- Trong 5 nhdm tudi dupe nghien euu thi nhdm 12-

13 tuoi ed miPC tien then cdn thj cao nhat trong 3 nam

(2,35D/3 ndm), sau dd tdi nhdm 10-11 tudi (2,190/3

nam). Cham nhat Id nhdm 16-18 tudi (1,52D/3ndm)

TAI LIEU THAM KHAO

1. Fan D. S, et al. (2004) "Prevalence, incidence,

and progression of myopia of school children in Hong

Kong". Invest Ophthalmol Vis Sci. 45(4)

2. Goss D. A (1994) "Effect of spectacle

correction on the progression of myopia in children-a

literature review". J Am Optom Assoc. 65(2): tr. 117-28.

3. Goss D. A and Rainey B. B (1998) "Relation of

childhood myopia progression rates to time of year". J

Am Optom Assoc. 69(4): tr. 262-6.

4. Goss D. A (1990) "Variables related to the rate of

childhood myopia progression". Optom Vis Sci. 67(8).

5. Hyman L, et al. (2005) "Relationship of age,

sex, and ethnicity with myopia progression and axial

elongation in the correction of myopia evaluation trial".

Arch Ophthalmol. 123(7): tr. 977-87.

6. Jensen H (1995) "Myopia in teenagers. An eight￾year follow-up study on myopia progression and risk

factors". Acta Ophthalmol Scand. 73(5).

7. Lin L.L (2001) "Epidemiologic study of the

prevalence and severity of myopia among school

children in Taiwan in 2000". J Formes Med Assoc. 100.

8. Mantyjarvi M. (1985) "Predicting of myopia

progression in school children". J Pediatr Ophthalmol

Srrad/smus. 22(2): tr. 71-5.

9. Ong E, et al. (1999) "Effects of spectacle

intervention on the progression of myopia in children".

Optom Vis Sci. 76(6): tr. 363-9.

10. Parssinen O and Lyyra A. L (1993) "Myopia

and myopic progression among schoolchildren: a three￾year follow-up study". Invest Ophthalmol Vis Sci. 34(9):

tr. 2794-802.

NHAN XET KET QUA DlTflTC DAU TRONG DIEU TRj UNG THlT MO DEM DIAN G TIEU HDA

GIAI DOAN MUON DAN G GLIVEC (IMATINID) TAI DENH VIEN K

TOM TA T

Nghien ewu nay dwgc thuc hien tai Benh vien K tir

thing 2/2007 din thing 3/2010, vdi 35 benh nhan u md

dem dwong tieu hda (GIST) ac tinh giai doan mugn,

dwgc diing Glivec hang ngiy vdi liiu 400mg, cho kit

qua nhw sau:

- Ti Ig dip img hoan tgan li 2,9%,; dip ung 1 phin li

62,7%o; benh giir nguyen la 28,6%o; tiin triin li 2,9%,;

DO HUNG KIEN, NGUYEN TUYET MAI,

NGUYIN THj THANH THOY va CS

Khoa Ngi I, Benh vien K.

mgt bgnh nhan dimg diiu tri (2,9%,).

- Khdng cd benh nhin nao tir vong trong diiu trj.

Phan Idn cic benh nhan dung nap thudc tot, ch! cd 2

trwdng hgp phai giam liiu 300 mg/ngay, 1 tnrdng hgp

phai giam liiu 200mg/ngay do ha bach cau, mgt mdi. !

- Cac tic dung phu diu xiy ra a mirc di? /, // khdng

phai can thiep dae biet

Tw khda: u md dgm dwang tieu hda, ic tinh, Glivec

80 Y HOC THl/C HANH (727) - SO 7/2010