Nguy cơ gây ung thư bàng quang của pioglitazon

Nguy CO gay ung thu

6uMg qumg cua pioglitazon -» DS. MAI XUAN DUNG

Pioghtazon Id hoat chit thupc

nhdm thiazolidinedion,

difcfc chi dinh ho trcf ehe

dfl an kiflng va tap the due nhim

cai thien sif kilm soat dUcfng huyet

or b^nh nhan d^ thdo difcfng typ 2.

Pioglitazon ed the difcfc SLT dung

don le hay ke't hop vdi cdc thuoe

dieu tri ddi thao di/dng khae nhif

nhdm sulphonylurea, metformin

hoge insulin.

Pioglitazon thudng difcfc trinh

bay d dgng thuoc vi&n vdi ham

lu'ong 15mg, 30mg, 45mg.

Ccf che ta c d^ng

ciia thud'c pioglitazon

Pioglitazon giup ting cifdng hogt

dong va gia t&ng sin xuit insulin

ndi tiit t6' giup dieu hda dirdng

huye't trong eo th^ vdi cac tae dgng:

- Lkm giam sir de khdng insulin;

- Lam tang sif nhgy cam cua

insulin, giup insulin hoat d6ng hieu

qui hcfn trong co the;

- Bao ve eae tg' bdo beta eua

tuye'n tuy, giiip keo dai thdi gian

sin xuit insulin trone ccf the.

Can lifu y

- Pioglitazon ehi phat huy tae

dung ha difdng huye't khi cd sif

hien dien cua insulin. Do do, khfing

nen sijf dung pioglitazon d benh

nhdn dai thdo du'dng typ 1 hoac

khi dieu tri nhiem ketoacid do dai

thdo difdng.

- Khong difdc stf dung eho ngifcfi

CO tien su! qua man vdi pioglitazon.

- Khi ph6'i hop pioglitazon vdi

insulin hay vdi ede thuo'c hg dudng

huyg't khdc co the din den nguy cO

ha difdng huye't ddt ngSt. Vi vdy,

can ehu y dieu chinh lieu dung eua

pioglitazon khi pho'i hop vdi ede

thuo'c nay,

- Pioglitazon kieh thich rung

trdng d phu nd tien man kinh. Vi

vdy, khi SLf dung pioglitazon cho

phu niJ trong thcfi ky tien man kinh

can phai cd cdc bien phap trdnh

thai phii hop!

- Kh6ng ddtfc sii" dung thuoc

pioglitazon cho ngifdi bi suy tim,

suy gan, phu niJ co thai hay dang

cho eon bu.

$, m §, m

H$ tiet nieu binh thddng He tiet nieu co khd'i u d bang quang

- Pioglitazon ed th i gay ra

nhieu tae dung phu vdi eae mde do

khdc nhau nha: nhilm triJng dUcfng

ho hap tren, dau dau, viem xoang,

dau CO, viem hau hpng, hg difdng

huyet, suy gan, phu ne, gay xifcfng,

ung thli bang quang...

Trong so rat nhieu tae dung phu

cua thuoe pioglitazon, can liru y^ de'n

nguy CO gdy ung thu bdng quang.

Tlf ndm 2011, Co quan Qudn

ly Thifc pham va Difcfc pham My

(PDA) da einh bdo nguy ctf gay ung

thir bang quang tang len de'n 40%

d nhijng ngadi co thdi gian suf dung

pioglitazon tren mot nam.

Sau khi cd eanh bdo cua FDA,

cac chinh phu d Phap, Ddc va An

Do da cam siJf dung pioglitazon. Vi

vdy, viee set dung pioglitazon ein

phii he't sde than trong. Ngadi

bgnh can phdi tudn theo chi dinh

dieu tri ciia thiy thufi'c mot each

ehgt che. Ne'u siJ dung thuo'c trong

mfit thcri gian dai, cin kiem tra

sdc khde dinh ky de phong trdnh

cde tdc dung nguy hilm do thufi'c

gay ra nhd nguy etf gdy ung tha

bang quang. ^

THUOC & SLfC KHOE so 510 (15.10.2014)