Nanotechnology Global Strategies, Industry Trends and Applications phần 9 doc

on fluorescent polymer nanofibre films have recently been reported [58, 59].

Preliminary results indicate that the sensitivities of nanofibre films to detect ferric

and mercury ions and a nitro compound (2,4-dinitrotulene, DNT) are two to three

orders of magnitude higher than sensitivities obtained from thin film sensors. A

single nanofibre coated with two metals at different segments will create a junction,

which can be made into a thermocouple to detect inflammation of coronary arteries

with extremely fast response times [60]. Such nanothermocouples can be inserted

into a cell to monitor the metabolic acticvities at various locations within the cell.

Furthermore, multiple nanothermocouples can be circumferentially mounted on a

catheter balloon to allow mapping of the arterial wall temperature [61].

8.8 Conclusion

Nanofibres and nanofibre structures are relatively recent materials. A number of

publications have appeared in recent years on specific polymeric nanofibers, their

processing methods and uses. See Figure 8.7 for a summary of next-generation

Figure 8.7 Summary and advantages of polymeric nanofibres for next-generation

applications

Next-Generation Applications for Polymeric Nanofibres 145

applications. However, there are several areas that require attention for further

development of the field. Potential applications of polymer nanofibres have been

recognized, but are mainly limited to the laboratory at present. Much greater efforts

will be required to commercialize these applications. As a result, research and

development of polymer nanofibres will continue to attract the attention of scien￾tists in the near future.

Acknowledgement

The authors acknowledge the efforts by M. Kotaki, R. Inai, C. Y. Xu and F. Yang of

the Biomaterials Lab at NUS, and Professor A. Yarin of Technion-Israel Institute

of Technology.

References

1. Martin et al., US Patent 4044404, 1977.

2. How T. V., US Patent 4552707, 1985.

3. Bornat A., US Patent 4689186, 1987.

4. Martin et al., US Patent 4878908, 1989.

5. Berry J. P., US Patent 4965110, 1990.

6. Stenoien et al., US Patent 5866217, 1999.

7. Scopelianos A. G., US Patent 5522879, 1996.

8. Athreya S. A. and Martin D. C., Sensors and Actuators, 72 (1999) 203.

9. Buchko C. J., Chen L. C., Shen Y. and Martin D. C., Polymer, 40 (1999) 7397.

10. Buchko C. J., Slattery M. J., Kozloff K. M. and Martin D. C., Journal of Materials Research, 15 (2000)

231.

11. Buchko J., Kozloff K. M. and Martin D. C., Biomaterials, 22 (2001) 1289.

12. Yang F., Murugan R., Ramakrishna S., Wang X., Ma Z. W. and Wang S., Biomaterials, 25 (2004) 1891.

13. Migliaresi C. and Fambri L., Macromolecular Symposia, 123 (1997) 155.

14. Laurencin C. T., Ambrosio A. M. A., Borden M. D. and Cooper J. A. Jr, Annual Reviews of Biomedical

Engineering, 1 (1999) 19.

15. Huang L., McMillan R. A., Apkarian R. P., Pourdeyhimi B., Conticello V. P. and Chaikof E. L.,

Macromolecules, 33 (2000) 2989.

16. Fertala A., Han W. B. and Ko F. K., Journals of Biomedical Materials Research, 57 (2001) 48.

17. Stitzel J. D., Pawlowski K. J., Wnek G. E., Simpson D. G. and Bowlin G. L., Journal of Biomaterials

Applications, 16 (2001) 22.

18. Boland E. D., Wnek G. E., Simpson D. G., Pawlowski K. J. and Bowlin G. L., Journals of

Macromolecular Science, A38 (2001) 1231.

19. Nagapudi K., Brinkman W. T., Leisen J. E., Huang L., McMillan R. A., Apkarian R. P., Conticello V. P.

and Chaikof E. L., Macromolecules, 35 (2002) 1730.

20. Li W. J., Laurencin C. T., Caterson E. J., Tuan R. S. and Ko F. K., Journals of Biomedical Materials

Research, 60 (2002) 613.

21. Matthews J. A., Wnek G. E., Simpson D. G. and Bowlin G. L., Biomacromolecules, 3 (2002) 232.

22. Xu C. Y., Inai R., Kotaki M. and Ramakrishna S., Biomaterials, 25 (2004) 877.

23. Lim T. C., Kotaki M., Yong T. K. J., Yang F., Fujihara K. and Ramakrishna S., Materials Technology,

19 (2004) 20.

24. Ignatious F. and Baldoni J. M., PCT/US01/02399, 2001.

25. Kenawy E. R., Bowlin G. L., Mansfield K., Layman J., Simpson D. G., Sanders E. H. and Wnek G. E.,

Journal of Controlled Release, 81 (2002) 57.

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