Kết quả điều trị loét dạ dày nhiễm HP bằng phác đồ esomeprazole - amoxycilline - clarithromycin (EAC) kéo dài 1 và 2 tuần

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Nghien ciru khoa hpc

KET QUA DIEU TRI LOET DA DAY NHIEM HP

BANG PHAC DO ESOMEPRAZOLE-AMOXYCILLINE

-CLARITHROMYCIN (EAC) KEO DAI 1 VA 2 TUAN

Nguyen Duy Thang*

TOM TAT

Dat van de: hit dg ddy nhiim Helicobacter pylori (HP) la binh phd biin tren the giai vd Viet Nam.

Muc tieu: nghiin cieu hiiu qud diiu tri phac dd EAC trong hit dg ddy nhiim HP. Ddi tuong va phuong

phap.- EAC 1 (30 binh nhdn) diiu tri trong mpt tudn. EAC 2 (30 benh nhdn) dieu tri trong 2 tudn. Ddnh gid

kit qud sau 1 thdng vd 6 thdng. Ket qua.- sau 1 thdng: ty le liin seo: EAC I 93,3%, EAC 2 96,7% (p> 0,05).

Ty le diet HP a EAC I 90,0%. d EAC 2 93,3% (p> 0,05). Giam dau: EAC I 93,3%, EAC 2 96,7%. Sau 6

thdng hit tdi phdt: EAC I 3,6%, EAC 2 0%. Ty li cdn tdn tgi HP a EAC 1 10,7% vd d EAC 2 69%. Dau

tdi phdt 3,6% ti'ong EAC I vd 3,4% trong EAC 2. Ket luan.- diiu tri hit dg ddy nhiim Helicobacter pylori

vdi phac do EAC trong mpt tudn vd hai tudn cd tdc dung liin seo, gidm dau vd diet HP nhu nhau. Sau 6

thdng EAC 2 khdng cd hit tdi phdt.

I. DAT VAN DE

Loet da day nhiem Helicobacter (HP) la benh

phd bien, cd the dien bien thanh ung thu neu khdng

dugc dieu trj tich cue. Cd nhieu phac do dieu trj

nham giam cac trieu chung lam sang, lam lien seo

d loet va quan trgng la diet trii- Helicobacter pylori.

Tuy nhien, van de tai phat loet va HP (+) van cdn

sau dieu trj cua mdi phac do khdng gidng nhau.

Theo ddi ngan han va dai han ket qua dieu trj loet da

day nhiem Helicobacter pylori van dang dugc quan

tam tren the gidi ciing nhu d Viet Nam. De gdp phan

tim hieu them van de tren, chiing tdi tien hanh de tai

nham muc tieu: ddnh gid hiiu qud cita phac do EAC

sau dieu tri 1 thdng vd theo doi sau 6 thdng tren ldm

sdng, hinh dnh npi soi vd diet trie HP.

II. DOI TirgfNG VA PHU'ONG PHAP

NGHIEN Cir u

1. Doi tuung nghien ciru

1.1. Tieu chiidn chpn benh nhdn

- Cd trieu chirng nhu dau thugng vj, g hoi, g chua,

day hoi, day bung khd tieu, budn ndn va ndn.

Tudi tir 20 den 65, khdng phan biet gidi tinh, nghe

nghiep. Dugc ndi soi tai Benh vien Ndng nghiep,

til- thang 2 nam 2007 den thing 2 nam 2009, chan

doan loet da day lanh tinh, cd HP (+). Tu nguyen

dieu trj theo 1 trong 2 phac dd nghien ciiu.

- Tdng sd 60 benh nhan, mdi nhdm gdm 30 benh nhan.

1.2. Tieu chuan loai trir

- Loet xuat huyet, ung thu hda, bd dd dieu trj hoac

khdng den soi lai theo dinh ky.

*Benh viin Ndng nghiep

86 53 (Thang 06/2010) Y HOC LAM SANG j 39