Góp phần nghiên cứu nicotiflorin trong cây chè vằng (Jasminum subtriplinerve Blume)

Nghien CLFU - Ky thuat

exhibited potent toxicity against all the three

cancer cell lines tested.

Keywords: Croton tonkinensis; ent-Kaurane;

Diterpenoid; Cytotoxicity

Tai lieu tham khao

1. Phan T6ng Son. Tran Bach Duong, Phan Minh

Giang, Nguyen Thi Minh. Hoang Thanh Huong. Le Mai

Huong. Khao sat hoat tinh khang vi sinh vat va gay dpc

te bao ciia cac alkaloid tu mot so loai Crinum ciia Viet

Nam, Tap cbi Dwgc hoc (2003), 43. 18-21 va 24.

2. Phan Minh Giang, Phan Tdng Son. Nghien cuu

hoat tinh gay doc t4 bao ciia cac diterpenoid day labdan

tu cay thuoc ich mau {Leonurus heterophyllus Sweet,

Lamiaeeae), Tap chi Dwgc hoc (2009), 49, 13-15,

3, Phan Minh Giang. Jin H, Z,. Pfian Tong Son.

Lee J, H,. Hong Y, S,, Lee J, J., enf-Kaurane

diterpenoids from Croton tonkinensis inhibit LPS￾induced NF-KB activation and NO production. J. Nat.

Prod. (2003), 66, 1217-1220,

4, Ptian Minh Giang. Ptian Tong Son. Lee J, J,.

Otsuka H,. Four enf-kaurane-type diterpenoids from

Croton tonkinensis Gagnep,. Chem. Pharm. Bull.

(2004). 52. 879-882,

5, Phan Minh Giang, Phan Tong Son, Hamada Y,.

Otsuka H., Cytotoxic diterpenoids from Vietnemese

medicinal plant Croton tonkinensis Gagnep,. Chem.

Pharm. Bull. (2005), 53, 296-300,

6, Vo Van Chi, Tw dien cay thudc Viet Nam, NXB

Y hpc, Thanh ph6 H6 Chi Minh (1997),

7, Sun H, D., Huang S. X., Han Q. B,,

Diterpenoids from Isodon species and their biological

activities, Nat Prod. Rep. (2006), 23. 673-698.

8, Phan Minh Giang. Le Thi Hong Dung. Phan

Tong Son, Chemical transformation of enf-kaurane￾type diterpenoids from Croton tonkinensis Gagnep. I -

Hydrolysis, Acetylation and Oxidation of enf-18-

acetoxy-7p-hydroxykaur-16-en-15-one. Tap chi Hoa

hoc (2007). 45, 382-385.

9, Phan Minh Giang, Nguyen Thi Thu Hang. Phan

Tong Son. Chemical transformation of enf-kaurane￾type diterpenoids from Croton tonkinensis Gagnep, 11

- Epoxidation of enf-18-acetoxy-7[5-hydroxykaur-16-

en-15-one. Tap chi Hoa hoc (2007). 45, 502-504,

10, Likhitwitayawuid K,. Angertioffer C. K., Cordell

G, A,, Pezutto J. M., Cytotoxic and antimalarial

bisbenzylisoquinoline alkaloids from Stephania

erecta, J. Nat. Prod. (1993), 56. 30-38,

Gop phan nghien cii'u nicotiflorin trong cay

che vang {Jasminum subtriplinerve Blume.)

Nguyen Quynh Huong ,

Nguyen Thj Hong Hu'o'ng'

'Khoa Y hgc co truyen,

'Khoa Duae, Dai hoc Y Duvc TP. Ho Chi Minh

Datvan de

Tir canh la cay che ving {Jasminum

subtnplinerve Blume hp Nhai. Oleaceae), chung

tdi da phan lap. xac djnh ciu triie mpt sd hgp

chit phenolic nhu rutin, astragalin, isoquereitrin,

verbascosid, isoverbascosid, oleoverbascosid,

apioverbaseosid, 6'-0-menthiafoloylverbaseosid

'^' va cung da xae dinh ham lugng eua nam

treng tam hgp ehit tren bing HPLC [1] va dien

di mao quan (CE) '^'. Tidp tuc nghien eiru ehiing

tdi xac dinh su ed mat eiia nicotiflorin va ham

luang cua nd trong dupe lieu nay dua tren du'

lieu phd MS va theo ky thuat HPLC.

Nguyen lieu va phu'O'ng phap

nghien CLPU

Nguyen lieu

Liy phin tren mat dit eua cay ehe ving,

phai khd, xay nhp thanh bpt Miu phan lap

duge thu hai vao thang 10-2006 tai Nghe An.

Cae miu djnh lugng the hien trong bang 1.

Bang 1: Cae miu che ving dung dinh Iwqng

trong dd tai

tl/lau

Noi thu hai

Dp am (%)

Thdi gian thu hai

Jass. 1

TP. HCM

9,21

10-2006

Jass. 2

Nghe An

9.35

5 - 2005

Jass. 3

Ha TTnh

9.45

5 -2005

T.AP CHi DUOC HOC-3/2011 (SO 419 NAM 51) 27