Đánh giá nhanh tỷ lệ mắt hột hoạt tính và quặm do mắt hột, tỷ lệ mù và các nguyên nhân chính gây mù ở cộng đồng 3 tỉnh Nam Định, Thái Bình, Hải Dương năm 2009

TCNCYH 70(SJ-2010

Summary

EFFECT OF WEIYANYIHA O O N CHRONI C ATROPIC GASTRITIS

Chronic atrophic gastritis (CAG) is one of the most common and difficult diseases in the tumors. It easy

to change into gastric carcinoma. Objectives: To describe histopathological changes of gastric tissue and to

evaluate changes in serum inflammatory factors in chronic atrophic gastritis rats treated by Weiyanyihao

formula. Method: 50 SD rats were modeling CAG in 20 weeks, radomisely devided into 6 grpups: model

group, control group, Weiyanyihao with high - dose, medium - dose and low - dose group and Weimeisu

group. By the end of treatment, isolating the serum, using of radioimmunoassay to measure serum IL - ip ,

TNF - a content; morphological observation at the same time. Results: The model group has significant

stomach membrane inflammation, gland atrophy and metaplasia. There is no significant dysplasia. There

are significant differences between Weiyanyihao groups and model group. It indicated that Weiyanyihao

formula has improvement effect on the histopathological changes in CAG. Compared with control group .

serum TNF - a content in treatment groups were increased,but only the model group had significantly dif￾ferent. Compared with model group, serum TNF - a in Weiyanyihao with middle and low - dose groups

and Weimeisu group were significantly lower, and in Weiyanyihao. Conclusion: Weiyanyihao can

improve histopathological changes of of experimental CAG in rats . Weiyanyihao can reduce the

inflammatory cytokines TNF - a content.

Keywords: Weiyanyihao, Chronic atrophic gastritis, TNF - a

DANH GIA NHANH TY LE MAT HOT HOAT TINH VA

QUAM DO MAT HOT, TY LE MU vA CAC NGUYEN NHAN CHINH

GAY MU 6 CON G DONG 3 TINH

NAM DjNH, THAI BINH, HAI DUON G NAM 2009

Nguyen Chi Dung

Benh vien Mit Trung uang

Danh gii ty Id mit hdt boat tinh d tre em dddi 16 tdoi va ty le qdSm do mit hot d ngddi td 40 tuoi trd

l&n di lip kd hoach thanh toin mit hdt d 3 tinh. Muc tieu: (1) Xic djnh ty le mit hot boat tinh d tre em dddi

16 tuoi va t'y le quim do mit hot d ngddi td 40 tuoi trd len (2) Dinh gia ty le mu va cic nguyen nhin chinh

gay mu d ngddi td 40 tudi trd len. Doi tugng va phuang phap nghien cdu: nghien cdu cit ngang tren 5201

tre em dddi 16 tuoi vi 9554 ngddi td 40 tdoi trd len. Ket qua: ty le mit hot hoat tinh d tre em dddi 16 tudi

tai 3 tinh li 0%o. Ty le quam do mit hot d ngddi td 40 tudi trd len li 4,48%o d Thai Binh, l,44%o d Nam Djnh

va 1,28%, d Hai Ddang, chu yeu d nhdm ngddi tren 70 tudi. Ty le mu 2 mit d ngddi td 40 tddi trd len li

4,17%o d Thii Binh, 2,62%o d Nam Djnh va 7,24% d Hai Ddang. Nguyen nhan giy mu chu yeu vin la due

the thuy tinh (DTTT): 3,3%, d Thii Binh, 2,3%o d Nam Dinh, 0,9%o d Hai Ddang. Ty le md do mit hot cao

0,1 %o d Thii Binh, thi'p 0,03%o d Nam Djnh va 0%o d Hai Ddang. Kit luan: de kiem soat benh mit hot giy

mil phai day manh mo quam, die biet d Ida tuoi dudi 70 la muc tieu cd the dat duac.

TO khoa: danh gia mat hot va quam

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