Đánh giá bước đầu tác dụng hỗ trợ điều trị đái tháo đường Týp 2 của bài thuốc

DANH GIA BUIDTC DAU TAC DUNG H 6 TRO DIEU TRj DAI THAO DUIDTNG TYP 2

CUA BAI THUOC GIANG CHI TIEU KHAT LINH

TOM TAT

Miic Heu: 1. Bw&c diu nghidn ciru tic dgng cua bii

thuoc doi v&i bgnh nhin DTD typ 2 thdng qua mgt so ehi

tieu lim sing vi cgn lim sing. 2. Theo ddi mgt so tie

dgng khdng mong muon eua bii thuoc. Doi twgng,

phwong phap nghien cCru: 70 BN dtrgc ehin doin

DTD typ 2, chia 2 nhdm. Nhdm nghidn cim udng bii

thu6c"Gling chi tidu kbit linh"vi 1 vidn Zidenol 80mg.

Nhdm chimg uong 2 vidn Zidenol 80mg/ngiy. Thai gian

dieu tri 3 thing. Nghien cim lim sing cd doi chimg, so

sinh kit qua tnr&c vi sau dieu tri. Kit lugn: khi uong

kit hgp bii thu6c"Giing ch! tidu khat linh"vi 1 vien

Zidenol 80mg/ngiy lim on dmh dtrang huyet ciia bgnh

nhin < 7,0mg; lam hg huyit ip vi him lirgng

cholesterol miu toin phin a bgnh nhan ed kit hgp tang

huyet ip hoge tang lipid miu. Bii thuoc khdng ed cic

tic dgng khdng mong muon

Tir khda: dii thio dtrang typ 2, giing chi tieu kbit

Hnh

SUMMARY

EVALUATE THE SUPPORTIVE EFFECT OF"GIANG

CHI TIEU KHAT LINH"REMEDY IN TREATMENT OF

TYPE 2 DIABETES

Objective: 1. To study on the effect of the

remedy"Giang chi tieu khat linh"on type 2 diabetes. 2. To

find out side - effects of the mmedy. Subjects: 70

patients diagnosed definitely type 2 diabetes, divided

into 2 gmups: study gmup of 36 patients wem tmated by

the"Giang chi tieu khat linh"and 1 tablet Zidenol

80mg/day, control group of 34 patients were treated by 2

tablet Zidenol 80mg/day. Method: open - clinical trial,

comparison of pre and post treatment. The study

duration lasted 3 months. Conclusions:

combination"Giang chi tieu khat Hnh"and 1 tablet Zidenol

8 mg/day keep blood glucose on type 2 diabetes

patients to be settled under 7.0 mmol/l, reduced blood

presum and cholesterol on patients who wem

hypertension and highlipldemia. The mmedy has no

unexpected effects

Keywords: diabetes, giang ehi tieu khat linh

OAT VAN Dfe

Oai thao dudng (OTO) la benh chilm 60 - 70% trong

sd cac benh npi tilt, trong dd DTD typ 2 chilm tdi tren

90%. cae tac dpng eua cupc sdng lam bpnh cang tang

nhanh d hau hit cac nude. OTO typ 2 la bpnh tiln triln

keo dai, cd nhilu biln chung d tim, mgch, thgn, co

khdp...Vi thi, DTD typ 2 cin dupe dilu tri va phdng

bgnh sdm d l han chi biln chirng cho bgnh nhan. Nam

1980, uy ban chuyen gia cua To churc Y t l thi gidi v l

benh DTD da khuyin nghj nghien ciru san xuit cac

thude udng eua YHCT de dilu tri benh DTD. Bai

thudc'Giang chi tieu khat linh"cd tac dgng tu am, bd khi,

bd thgn, hogt huylt hda u thich hpp vdi bgnh nhan DTD

typ 2 nhung ehua dupe nghien cuu danh gia mpt each

TRAN THI HAI VAN

Khoa YHCT- DH YHi Ngi

cd he thdng. Vi v^y, chung tdi tien hanh d l tai niy v6i

mgctiSu:

- Bw&c dau nghien cim tie dicing cua bii thuoc Ooi

v&i bgnh nhin dii thio dw&ng typ 2 thdng qua mgt so

ehi tidu lim sing vi cgn lim sing

• Theo ddi mgt so tic dgng khdng mong muon cua

bii thudc

D 6 I TU'ONG, PHLCaNG PHA P NGHIEN CLCU

1. Chit ligu nghien ci>u

1.1. Thinh phin bii thude"Giang ehi tieu khat lintt":

Linh chi (12g), Dan sam (12g), Hoang lien (06g), Ha thu

d (12g), Trgch ta (12g), Son tra (08g), Nguu tit (12g),

Thien hoa phin (12g), Hoang ky (12g). Thudc du^c

diing dudi dgng thude thang sic dgc

1.2. Thude doi ehwng: Zidenol 80mg/vien, dgng vien

nen

2. Ddi tuo-ng nghien cii'u: 70 bgnh nhan d ca 2

gidi, duoc chin doan la DTD typ 2, dilu tri tgi khoa

Kham benh va khoa Ndi 3, Benh vign da khoa YHCT Ha

Npi

2.1. Tidu chuan chin doin theo YHHD:

- Bpnh bit diu sau tudi 35, benh nhan thudng beo,

khdi phat benh tu tu

- Dya vao 1 trong 3 kit qua xet nghiem sau:

+ Ndng dp dudng huylt mau tTnh mgch trong mot

mau mau bat ky > 11,1 mmol/l (200mg/dl)

+ Ndng dp dudng huylt mau tTnh mgch luc doi ky i

7,0 mmol/l (126mg/dl) (sau 8 gid khdng an)

+ Ndng dp dudng huylt mau tTnh mgch sau khi uong

75mg glucose 2 gid > 11,1 mmol/l (200mg/dl)

- Dilu tri bing thudc udng hg dudng huylt cd hi§u

qua

2.2. Tieu chuin ehin doin theo YHCT

- Tieu khat thup'ng tieu: reu luoi vang mdng, dau

luoi dd, khat nudc udng nhilu, hpng khd, hay di tiiu vat

nhilu lln, mgch hdng sac

- Tieu khat trung tieu: reu luoi vang, an nhieu mau

ddi silt can, dgi tign tao, mgch hogt thyc

- Tieu khat hg tieu: reu ludi vang, migng kho hpng

rao, ndng trong ngudi, di tiiu nhieu lln, sd lupng nhieu,

dau lung mdi gdi, mgch trim t l sac

2.3. Tieu chuan logi trw

- Bgnh nhan dang ed cac biln chung elp tinh cua

DTD nhu: nhiem toan ceton, nhiem trting ngng, suy gan,

suy thgn, suy tim

- Bgnh nhan cd tiln sir: nhdi mau co tim, dau thJt

ngye, thiiu nang vanh, TBMMN, basedow....

- Benh nhan khdng tuan thii quy trinh nghiSn ciru, bo

thudc

3. Phurong phap nghien CLPU

- Nghien cuu thir nghiem lam sang md, c6 d6i

chung, so sanh kit qua trudc va sau dieu \x\

3.1. Quy trinh nghien cim

- Tham kham toan dien cho benh nhan. Ap dgng che

86 Y HOC THlJC HANH (751) - S6 2/2011