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TCNCYH 68 (3) - 2010
Summary
INVESTIGATION ON ADVERSE DRUG REACTIONS OF ANTI - TUBERCULOSIS
MEDICATIONS IN TWO TUBERCULOSIS HOSPITALS
Objectives: To determine the frequency and type adverse drug reactions (ADR) of anti - tuberculosis
medications in the two tuberculosis hospitals. Methods: Retrospective method was used to collect
information from 1060 medical charts of in - patient who was treated in the two tuberculosis hospitals
during 2005 - 2006. The nature of ADR, symptoms and the timing of their onset, as well as subsequent
modifications in the treatment regimen, were investigated. Results: The proportions of patients had side
effects were 16.32%. The most common reactions were those involving the skin (58.96%), the
gastrointestinal tract (24.85%). Adverse reaction was common in the first week of the treatments
(56.07%). Modification regimen was neseessary in 41 cases (23.7%) and stop tuberculosis treatment was
1 8.5%. Conclusions: In 1060 tuberculosis patients, the frequency of adverse reaction related to medication
treatment was 16.32%. However, 23.7% of the cases were neseessary to modify the treatment regimen
due to side effects and 1 8.5% of the cases had to stop treatment by antituberculosis medications.
Keywords: tuberculosis, adverse drug reactions, anti - tuberculosis medications
CAC BIEU HIEN LAM SANG VA DANH GIA KET QUA
DIEU TRI CUA VIEM TAY VA AP - XE QUANH AMIDAN TRONG T/\l
BENH VIEN TAI MUI HONG TRUNG UONG
* Pham Tran Anh, Pham Khanh Hoa
Trddng Dai hoc Y Ha Ndi
Muc tieu: md ta ddc diem lam sdng cua viem tay vd dp - xe quanh amidan. Dd'i tugng va phuang phap
nghien cdu: nghien cdu tien cdu theo phddng phdp phan tich thdng ke md ta 30 benh nhan VTQA vd AQA
da duqc chan dodn lam sang vd dieu tri bdng thudc khdng sinh tai khoa cap cdu Benh vien Tai Mui Hong
Trung dang td thdng 10/2006 den thdng 10/2007. Ke't qua: nhdm tudi td 15 - 30 tudi chiem 34,78%). Trieu
chdng lam sang: bieu hien toan than nhiim triing todn than 66,67%. Trieu chdng ca nang: Trieu chdng dau
cd 83,33%.Tneu chdng nudt dau va quay cd ban che 75,00%. Trieu chdng thdc the: Sdng tay vung cd gap
100% Trieu chdng can lam sang: X Quang cd nghieng: day phan mem CS cd 56,55% trddng hap. Bien
chdng 69,56%; (2) Phau thudt chiem 95,65%. Ket qua dieu tri: khdi benh 86,95%. Ke't luan: (1) Viem tay
mil ben co cd the gap d moi Ida tudi, tudi trung binh Id 34,57. Viem tay mu ben cd cd ty le bien chdng khd
cao. Can thiep phau thuat Id chu ye'u. Dieu tri khdng sinh phdi hap gida mot Cephalosphorine the he 3 vdi
Metronidazole cho ket qua tdt chie'm tl le cao. Ty le khoi cao, chiem 86,95%.
Tii khoa: viem tuy, ap xe quanh amidan, diing khang sinh
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