Towards the use of CD1 presented mycobacterial lipids in vaccines: Doctor Thesis - Major: Immunology

Towards the use of CD1 presented

mycobacterial lipids in vaccines

The research described in this thesis was conducted from October 2007 to October 2011 at

the Division of Immunology, Department of Infectious Diseases and Immunology, Faculty

of Veterinary Medicine, Utrecht University, the Netherlands.

Cover design: Anjolieke Dertien

Front cover: GMM is inserted into CD1b molecule (adapted from Batuwangala et al., The

Journal of Immunology, vol 172 pp.2382-2388, 2004 with the reprint permission from JI.

Copyright 2004. The American Association of Immunologist, Inc.)

Back cover: Mycobacterial cell wall that comprises thick different lipid layers

Lay-out: Nguyễn Thị Kim Anh

Printed: by Wörhmann Print Service, Zutphen, The Netherlands

ISBN: 978-90-393-5626-5

The research described in this thesis was fi nanced by a grant from the Vietnamese Government

(Project 322)

Financial support for printing of this thesis was received from the Infection & Immunity

Center Utrecht.

Towards the use of CD1 presented

mycobacterial lipids in vaccines

Op weg naar het gebruik van CD1 gepresenteerde

mycobacteriële lipiden in vaccins

(met een samenvatting in het Nederlands)

Hướng tới việc sử dụng kháng nguyên lipit từ mycobacteria

được trình diện qua phân tử CD1 trong vắc-xin

(với bản tóm tắt tiếng Việt)

Proefschrift

ter verkrijging van de graad van doctor aan de Universiteit Utrecht

op gezag van de rector magnifi cus, prof. dr. G.J. van der Zwaan,

ingevolge het besluit van het college voor promoties in het

openbaar te verdedigen op maandag 3 oktober 2011

des middags te 12.45 uur

door

Nguyễn Thị Kim Anh

geboren op 28 juni 1974 te Hà Bắc, Vietnam

Promotoren: Prof. dr. W. van Eden

Prof. dr. V.P.M.G. Rutten

Co-promotor: Dr. I. van Rhijn

For my parents