Tác dụng của Lercanidipine trên huyết áp ở bệnh nhân nhồi máu não có tăng huyết áp - kết quả từ 52 bệnh nhân được đo lưu động 24 giờ

thu thuSt ihdng thudng

4. Yiu td lien quan d in dau khi Idm thu thudt

Thdi gian kh6 c ngdn han Id 47s a nhbm dung

G30% so vdi nhdm dung nude Celt thdi gian khde

trong qud trinh Idm thu thudt Id 112s (p<0,001). Theo

Blass EM, 1992 cho thiy d nhdm bdnh nhdn dung

G30% thdi gian khde Id 43s so vdi nhdm khdng dung

G30% Id 105s (p<0,001) [4] vd tren mdt ket qua

nghidn cuu thu nghiem khde trong 3 phut diu vdi

nhdm tre dung G30% ting thdi gian khde Id 1s so vdi

nhdm dung Emla giam dau Id 18s [5], V i nhip tim,

tdng Idn trong qud trinh Idm thu thudt vd giam dan v i

trang thdi ban diu sau khi Idm thu thudt.

Trong khi Idm thu thudt nhjp tim d nhdm dung

G30% (1821/ph) thip han so vdi nhdm dung nude c it

(1981/ph) vd sau thu thudt b nhdm dung G30% Id

1491/ph vd d nhdm dung nubc c it Id 1681/ph

(p<0,05). Mlpc dd dau cung Idm anh hudng din tin

so tim d nhdm tre 2-12 thdng. Tuy nhien, so sdnh kit

qua ndy vdi mdt s6 k it qua nghien cuu hidu qua

G30% tren tre sa sinh thi khdng cd su khde biet v i

tan s6 tim giu,a nhdm dung G30% vd nhdm khdng

dung G30% [1], [5]. Vide su dyng dung dich G30%

rit dan gian, chi cin 3-5ml bdng dudng mi&ig dd

cho thiy hidu qua giam dau. Trong nghidn cuu chua

thiy cd biiu hidn tdc dung phu khi dung 3-5ml dung

dich G30% cho tre khi Idm thu thuat. K it qua ndy

cung trung vdi k it qua cua nhiiu tdc gia nghien cuu

v i vin d i ndy [1], [3], [7],

k £t l u a n

Muc dd dau cua tre trong vd sau khi Idm thu thudt,

bang 3 cho thiy cd su khde biet rd ret cd y nghTa

thong kd giua nhdm dung nude cat vd nhdm dung

G30% vdi muc “khdng dau, dau nhe" vd “dau vua"

trong khi Idm thu thudt tu 0-15s, tu 15-30s vd tu 30-

60s (p < 0 .0 0 0 1 ).

Diim dau trung binh trong khi Idm thu thudt d

nhdm dung nude c it cao han gip ddi so vdi nhdm

dung G30% trong khi lam thu thuat o' thdi diim tu 0-

15s, tu 15-30s vd 30-60s. Su khde biet rat rd ret cd y

nghTa thing ke vdi p<0,001. Diem dau trung binh sau

khi Idm thu thudt giam nhieu d nhdm dung G30% sau

thu thudt so vdi nhdm dung nirdrc c it Su khde bidt

rit cd y nghTa thing kd (P<0.001) Thdn gian khde

trong vd sau khi Idm thu thudt cua nhdm dungnubc

c it ddi han so vdi nhdm dung G30% (p<0,001) Cd

su khde bidt rd rdt cd y nghTa thdng kd giua hai nhdm

vdi p<0,001 v i tin s i tim trong khi Idm thu thudt d

nhdm dung nu’bc c it cao han so vbi tin s i tim cua

nhbm dung G30% V i tin s i tim sau Idm thu thudt

giam din b ca hai nhbm nhung giam nhanh han b

nhbm dung G30%.

TAI LIEU THAM KHAO

1 Le Thj Hoa Binh, Dao Thi Hong Kidn (2006),

“Nghien cuu hieu qua cua dung djch glucose 30% giup

giam dau cho benh nhi khi lam thu thudt tai khoa So

sinh - Benh vien Nhi Trung TW, Hoi nghi khoa hoc diiu

dudng Nhi Khoa todn quoc, trg 43 - 48

2. Muller (Thi ky 19), Thuyit ddc hieu" (tdi li$u

dich).

3. Bauer K, K.J, Hellwig M, Laurenz M, Versmold H

(2004), “Oral glucose before venipuncture relieves

neonates of pain, but stress is still evidenced by

increase in oxygen consumption, energy expenditure,

and heart rate”, Pediatr Res, pg. 695 - 700

4. Blass EM, S.D. (1994), "Some comparisons

among the calming and pain - relieving effects of

sucrose, glucose, fructose, and lactose in infant rats",

Chem Senses, pg. 239 - 249

5. Gradin M, E.M., Holmqvist G, Holstein A, Schollin

J. (2002), “Pain reduction at venipuncture in newborns:

oral glucose compared with local anesthetic cream",

Pediatrics, pg.1053 - 6 .

6. Harrison D, S.B., Bueno M, Yamada J, Adams -

Webber T, Beyene J, Ohlsson A. (2010), 'Efficacy of

sweet solutions for analgesia in infants between 1 and

12 months of age: a systematic review", Arch Dis Child,

pg. 406-413.

7. Harrison D, Y.J., Adams - Webber T, Ohlsson A,

Beyene J, Stevens B (2011), “Sweet tasting solutions for

reduction of needle - related procedural pain in children

aged one to 16 years”, Cochrane Database Syst Rev,

pg. CD008408. Efficiency of 30% glucose solution

HELP.

TAC DUNG CUA LERCANIDIPINE TREN HUYET AP Cf BENH NHAN NHOI MAU NAO

CO TANG HUYET AP- KET QUA TUT 52 BENH NHAN Dl/tfC DO LIAJ DONG 24 GI0

TOM TAT

Muc dich: Ddnh gid tdc dung ha huyet dp vd tdc

dung phu cua lercanidipine & benh nhdn nhoi mdu

nao cd tdng huySt dp bdng do huySt dp luv dong 24

gj&. Doi twang vd phirang phdp: Phirong phdp this

nghidm Idm sdng ng§u nhidn dan, trdn 52 bdnh nhdn

nhdi mdu ndo cd tdng huySt dp, 30 nam vd 22 nCr,

tudi tmng binh 64,6±9,7, t it cd bdnh nhdn dur?c theo

ddi huySt dp (HA) luv ddng 24 gib trong tuin diu,

CAO TRUONG SINH - Dai hpc Y khoa Vmh

sau dd dung lercanidipine 20 mg/ngdy 4 tu in r6i

mang mdy do HA luv ddng lin 2. Chuang trinh do 30

phut mdt lin vdo th&i gian ngdy (tir 6am - 10pm) vd

60 phut mdt lin vdo ban ddm (10pm-6am) Ket qud:

Sau 4 tuin dung lercanidipine, huydt dp & bdnh nhdn

nhdi mdu ndo cd tdng huySt dp gidm cd y nghla

(p<0,001): 17±10/ 8 ± 9 mmmHg d6i v&i HA 24 gi&,

18±11/8 ± 9 mmHg ddi v&i HA ngdy vd 14±16/7 ± 12

mmHg ddi v&i HA ban ddm. Ap li/c mach 24 gt& gidm

32 Y HQC THtfC HANH (907) - SO 3/2014