Những bước tiến mới trong điều trị ung thư

iiSMM

/|^H ^ Hoi nghi ung thu Asco

NhiJng bifdc tien mdi

trong dieu tri ung thif

pi nghi lan thfl 50 eua

Hifip hfii ung thfl ldm

-sang Hoa Ky (ASCO

*= American Society of Clinical

(3ncology) dflde to chflc tai Chicago

vdo thang 6 vfla qua, tgp hdp hang

van chuyfin gia quic tl . Nhieu

nghifin cflu ed b^n gdp phan lam

hilu rd hcfn cdc cd ehfi' phat trien

ung thfl.

Trong dilu tri, cd ra't nhieu

nghifin cflu giup keo dai sfl sd'ng

cua benh nhan ung thfl, nhd't la

d cde trfldng hdp ung thfl da cd

di can. Thach thfle d day Id kilm

sodt dfldc sfl phdt triln ung thfl

di bifi'n cdc ung thfl di can thdnh

bfinh man tfnh.

Ung thtf tien li#t tuye'n va ung

thtf vri da co phtfcfng pha p dieu

tri hi^u qua hofn

Nghifin cflu CHAARTED vl

ung thfl tien liet tuyln lfi thufic

hormon giai doan di can dfldc

Vien Quoc gia Y t l (NIH) vd

Vifin Quoe gia vl Ung thfl thfle

hifin. Thfl nghifim nay da theo

doi 790 bfinh nhan, cho thl'y: ne'u

phli hdp hda tri lifiu Doeetaxel

vdi phfldng phap hormon (nhlm

giam boat dpng eae androgen) ed

the kdo ddi hdn mfit ndm sfl sd'ng

ciia hfnh nhan hi ung thfl tien lifit

tuyln cd di can.

Phfldng phdp dilu tri ndy cd

t h i la phfldng phdp chuin ddnh

cho nam gidi hi ung thfl tiln lift

tuyfi'n lan tda md cd the chiu dfldc

hda tri lieu.

Mfit nghien eflu khac gpi ten

POEMS lien quan dfi'n ung thfl vu

khdng lfi thude hormon gpi y: ed

thi giup cac benh nhan tre hi ung

thfl vu, sau thdi gian hda tri Ufiu cd

the ed eon dfldc nfi'u tifim m6i thdng

mdt miJi Goserelin, mpt hormon tao

mdn kinh tam thdi, Idm cdc buing

trflng ngflng hoat ddng. Goserelin

giam din 64% nguy cd suy ehflc

nang budng trflng. Phfldng phdp

ndy Id mfit giai phap dfi dang dp

dung de bao ve kha nang sinh sdn

so vdi vifie trieh vd ddng lanh noan

bdo trfldc khi dp dung hda tri lifiu.

Kha nan g dil u tri tnin g dich

tan g do'i vdi cac ca un g thtf

a c tinh

Da cd cde phdn tfl dae bifit dang

dfldc dp dung cho mfit so ung thfl.

Cde nhd san xuat dang dilu chfi'

vd thfl nghiem khodng 900 phan

tfl danh eho dilu tri trung dfch.

Cdc phdn tfl ndy nham vdo cac hit

thfldng d cac te bdo ung thfl, nham

vdo eae thu th i hay protein trong

te'bao ung thfl. Cae bat thfldng ndy

kilm sodt hodc kieh thich sfl phdt

triln ung thfl. Cae phan tfl dilu

Recepteurs

\\atiBg ^*%»V L Herceplin '

^^^^^^rD K

M^t sd tdbAo CO d mat ngoii rit nhieu

th^i th4 ErbB2. Cac thu thi nay thuc diy

cdc ti bio phdn chia rat nhanh

THUOC & stfc KHOE sl508 (15.9.2014)

Herceptin gan vio cac thu thi

ErbB2, dc che sU phat triin 6 at

eCia cac te bko

0 dieu che duac

Glivec, Cong ty

Novartis da nhan duac

giai Galien nSm 2002

tri trung dfch, khdng tan cdng ede

te' bao lanh, khong thay the' ede

phfldng phap dieu tri cl dien (hda

tri lieu, xa tri) md chi bl sung

de tan cdng ung thfl, nha't la cdc

trfldng hop ung thfl da cd di cdn.

Trong cdc phan tfl trung dieh,

phdi kl cde khdng the ddn ddng

vdi tifi'p to "mab" vd ede phdn tfl

nhd "flc che^ vdi tie'p td' "inib". Cdc

phdn tfl "mab" Mm ham sfl phdt

trien cua thu the d be mat cdc te

bdo ung thfl. Cdc phdn td "inib"

chui vao te'bdo ung thfl, ngan chgn

hoat dfing cua te' bdo ung thfl.

Mfit so' dflde pham dieu t n

trung dich da td ra rat hflfl hifiu

nhfl Glivec (imatinib) ehi dinh cho

bfinh baeh d u tuy man, flc ehe'

enzym dot bie'n, tao sfl phdt trien

6 at cac bach eau, hay Herceptin

(trastuzumab) giam dfi'n 50% nguy

CO tai phat ung thfl vu ed thu the

HER2 so vdi hda tri lieu.

Cac dfldc pham tan cong trung

dich cdn cd kha nang tan cdng cac

nang bfldu khang vdi cdc phfldng

phap dieu tri co dien.

Lenvatinib han chl sfl phdt

triln ung thfl dc tinh tuyfi'n gidp,

khdng vdi iod phdng xa.

Dd'i vdi bfinh ung thfl dai trfle

trdng di cdn (nhflng khdng cd dot

biln KRAS), hai khdng the ddn

ddng bevacizumab vd cetuximab

phfi'i hpp vdi hda tri lieu, cd kha C

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