Mô tả kiến thức, thái độ, thực hành phòng chống các bệnh lây truyền qua đường tình dục và HIV/AIDS của thanh thiếu niên dân tộc thái 14-24 tuổi tại xã Tông Lạnh, Thuận Châu, Sơn La

BAN LUAN

1. Bie'n doi AT III :

AT III ed vai trd Ue che thrombin ehu ye'u, nd cung

Lfc che cae ye'u td Vila, IXa, Xa, Xlla vd plasmin, theo

mpt sd tae gia AT III thudng giam d benh nhdn HCTH

do md't qua nUde tieu do trpng lUpng phan tur nhd

[6],[7]. Nghien ciiru chung tdi tha'y gia trj trung binh eua

AT III Id 102,83 ± 23,71, ed giam so vdi gid tri trung

binh AT 111 d nhdm chimg co y nghTa thdng ke (p <0,01)

2. Bie'n doi protein S

Protein S Id mpt protein phu thupc vitamin K, nhUng

khdng phai Id mpt enzym. Khi ndng dp protein S trong

huye't thanh giam thi hoat tinh khang ddng cua protein

C bj giam va khi them protein S vdo thi hoat tfnh cua

protein C trd lai binh thudng. Cae tae gia ke't luan rang

giam protein S la ye'u td nguy cd lam phat then bie'n

chifng tae mach, va trong HCTH giam protein S eung

ed the la do mat qua nUde tieu do trpng lUdng phan tif

nhd [1],[3],[4]. Trong nghien cifu eua chiing tdi, gid trj

tmng binh protein S la 98,25 ± 16,37, giam hdn b

nhdm chifng cd y nghTa thd'ng ke (p <0,01)

3. Bie'n doi protein C

Protein C la mpt zymogen phu thupc vitamin K,

protein C cd vai trd bat hoat cac ye'u td V va VIII, Khi

ndng dp protein C giam dUdi 50% so vdi mifc binh

thudng se din tdi tang ddng va nghen maeh

[1].[3]i[4]. Trong nghien eifu eija ehung tdi, gia tri

trung binh protein C la 119,13 ± 21,12, khdng khac

biet so vdi nhdm chifng (p > 0.05).

3. Bie'n doi fibrinogen

Takeda.Y va Chen A [5],[10] da quan sat tha'y d

benh nhan cd HCTH ndng dp filDrinogen mdu tang rat

cao, cd the tdi 10g/l va cd lam thay ddi dp nhdt cua

mdu. Tang fibrinogen trong mau la do tang tdng hdp d

gan, dUdng nhU tang ndng dp fibrinogen ed the ddng

vai trd quan trpng trong tinh trang tang dong mau d

benh nhdn cd HCTH. Qua nghien cifu ehung tdi thay

phan Idn benh nhan ed lUdng fibrinogen tang (79%).

4. Bien do'i ye'u to V, VIII

Ndng dp cae ye'u td V, VIII tang trong mdu d benh

nhdn VCTM cd HCTH da dUde nhieu tdc gia de cap

de'n [2], [9]. NgUdi ta cho rang tang cac ye'u td V va

VIII Id do gan tang tdng hdp cae ye'u td nay^tai gan.

Giam dp ed ddc eua huyet tUdng vd/hode giam ndng

dp albumin huyet tUdng la ye'u td kfch thi'ch cae te bao

gan tang san xua't cac protein. Nghien cifu cua ehiing

toi tha'y rang 84,5 % benh nhan cd tang yeu td V va

87,5 n % benh nhan ed tang ye'u td VIII.

KET LUAN:

6 benh nhan HCTH nguyen phat ngudi Idn ed

nguy ed tdng dong do giam AT III v protein S ; Tang

fibrinogen, ye'u td dong mau V va VIM

TAI LIEU THAM KHAO

1. Adier A.J., Ludin A.P.: Thromboglobulin levels in

the nephrotic syndrome Am J med, 1980; 69: 551-4

2. Andrassy K.; Ritze, Bonner.J: Hypercoagulability

in the nephrotic syndrome Klin Wochenschr 1980(61),

58: 1029-36

3. Com P.P. , Esmon C T. : recurrent venous

thromboembolism in patients with a partial deficiency of

proteins, IvengI J med 1984; (61); 311: 1525-8

4. Garcia - Maldonodo M., Com P.: Protein C and

Protein S are not low in diabetic, nephropathy. Kidney Int

1989

5. Hoffbrand A.V., and Pettit J.E.: Essential

Haematology, Oxford Blackwell scientific publication,

4thedi, 1993; P: 306; 311

6. Kauffman R.H., Velt Kam P.J.J.,Vaan ESLA:

Acquired antithrombin III deficiency and thrombosis in

the nephrotic syndrome. Am J med 1978; (61);65:607-13

7. Kuhlmann U., Stevver J., Rhyner K., Von felten

A., Briner, J., Siegenthaler W.: Platele aggregation and

thoromboglobulin levels in the neprotic patients, with and

without thrombosis. Clin nephrol 1981; (61); 15: 299-35.

8. L.Lach P., Koffler A., Frine K.E., Massry S.G.: on

the incidance renal vein thrombosis in the nephrotic

syndrome. Arch intern med 1997; (61); 137:33-6

9. Thompson C, Forbes CD., Nentice C.R.IVl.,

Kennendy A.C: Changes in blood coagulation and

fibrinolysis in the neohrotie syndrome. QJ med 1974:

(61); 43: 399-407

10.Takeda Y., Chen A.: Fibrinogen metabolis and

distribution in patiens with the nephrotic syndrome; J lab

Clin med 1967; (61); 70: 678- 8511.

MO TA KIEN THIJfC, THAI DO, 1H\SZ HANH PHONG CHONG CAC BENH LAY TRUYEN QUA

DO&NG TINH DUC VA HIV/AIDS CUA THANH THIEU NIEN DAN TOC THAI

14-2 4 TUOI TAI XA TONG LANH, THUAN CHAU, SON LA

vu VA N HOAN, Vien Chien luge vi Chfnh sich y fe￾LE LAN HUONG, Vy To C/7UC C^n ftp, ep Yfe

NGUYI N THANH HaONG, Trudng Dai hgc Y tecong cong

TOMTAT:

Muc tieu: Md ta kien thirc, thai dg, thwc hinh va mdt

so yiu to lien quan vi phdng.chong cic bgnh lay tmyin

qua dwong tinh due (PC STDs) vi HIV/AIDS ciia thanh

thieu nien dan tgc Thai 14-24 tuoi tai xa Tdng Lanh,

huyen Thuin Chiu, tinh Son La.

Doi twgng vi phwong phap nghien ciru: Nghien ciru

md ta cat ngang a nam, nu- TTN dan tgc Thii 14 - 24

tuoi chwa lap gia dinh tai xa Tdng Lanh.

Kit qua: Ty le doi twang nghien ciru (DTNC) dat yeu

Y HOC THUC HANH (727) - SO 7/2010 85