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Molecular Basis of Heredity
What an organism looks like and how it functions is
determined largely by its genetic material. The basic
principles of heredity were developed by Gregor Mendel,
who experimented with pea plants in the 19th century.
He mathematically analyzed the inherited traits (such as
color and size) of a large number of plants over many
generations. The units of heredity are genes carried on
chromosomes. Genetics can explain why children look
like their parents, and why they are, at the same time, not
identical to the parents.
Phenotype and Genotype
The collection of physical and behavioral characteristics
of an organism is called a phenotype. For example, your
eye color, foot size, and ear shape are components of
your phenotype. The genetic makeup of a cell or organism is called the genotype. The genotype is like a cookbook for protein synthesis and use. Phenotype (what an
organism looks like or how it acts) is determined by the
genotype (its genes) and its environment. By environment, we don’t mean the Earth, but the environment
surrounding the cell or organism. For example, hormones in the mother’s body can influence the gene
expression.
Reproduction
Asexual reproduction on the cellular level is called mitosis. It requires only one parent cell, which, after exactly
multiplying its genetic material, splits in two. The resulting cells are genetically identical to each other and are
clones of the original cell before it split.
Sexual reproduction requires two parents. Most cells
in an organism that reproduces sexually have two copies
of each chromosome, called homologous pairs—one
from each parent. These cells reproduce through mitosis.
Gamete cells (sperm and egg cells) are exceptions. They
carry only one copy of each chromosome, so that there
are only half as many chromosomes as in the other cells.
For example, human cells normally contain 46 chromosomes, but human sperm and egg cells have 23 chromosomes. At fertilization, male and female gametes
(sperm and egg) come together to form a zygote, and the
number of chromosomes is restored by this union. The
genetic information of a zygote is a mixture of genetic
information from both parents. Gamete cells are manufactured through a process called meiosis, whereby a cell
multiples its genetic material once, but divides twice,
producing four new cells, each contains half the number
of chromosomes present in the original cell before division. In humans, gametes are produced in testes and
ovaries. Meiosis causes genetic diversity within a species
by generating combinations of genes different from
those present in the parents.
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Cytoplasm
Endoplasmic
reticulum
Plasma
membrane
Nucleolus
Nucleus
Vacuole
Cell wall
Ribosomes
Mitochondria
Centriole
Chloroplast
Lysosome
Plant Cell Animal Cell
Golgi
complex